ArticleJournal of virology2004
Activation of transcription factor Nrf-2 and its downstream targets in response to moloney murine leukemia virus ts1-induced thiol depletion and oxidative stress in astrocytes.
Article in Journal of virology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 79 citations in OpenAlex.
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- A Study on the Planarian Model Confirms the Antioxidant Properties of Tameron against X-ray- and Menadione-Induced Oxidative Stress.Antioxidants (Basel, Switzerland) · 2023Article
- Glutathione and Related Molecules in Parkinsonism.International journal of molecular sciences · 2021Review
- xCT: A Critical Molecule That Links Cancer Metabolism to Redox Signaling.Molecular therapy : the journal of the American Society of Gene Therapy · 2020Review
- Tryptanthrin Suppresses the Activation of the LPS-Treated BV2 Microglial Cell Line via Nrf2/HO-1 Antioxidant Signaling.Frontiers in cellular neuroscience · 2017Article
- Butein provides neuroprotective and anti-neuroinflammatory effects through Nrf2/ARE-dependent haem oxygenase 1 expression by activating the PI3K/Akt pathway.British journal of pharmacology · 2016Article
- Cytoplasmic vacuolization in cell death and survival.Oncotarget · 2016Review
- Serotonin 1A Receptors on Astrocytes as a Potential Target for the Treatment of Parkinson's Disease.Current medicinal chemistry · 2016Review
- Splicing of Friend Murine Leukemia Virus env-mRNA Enhances Its Ability to Form Polysomes.Frontiers in microbiology · 2016Article
- Role of miR-182 in response to oxidative stress in the cell fate of human fallopian tube epithelial cells.Oncotarget · 2015Article
- Expression of xCT and activity of system xc(-) are regulated by NRF2 in human breast cancer cells in response to oxidative stress.Redox biology · 2015Article
- Acerogenin A from Acer nikoense Maxim Prevents Oxidative Stress-Induced Neuronal Cell Death through Nrf2-Mediated Heme Oxygenase-1 Expression in Mouse Hippocampal HT22 Cell Line.Molecules (Basel, Switzerland) · 2015Article
- p53 as a retrovirus-induced oxidative stress modulator.The Journal of general virology · 2015Article
- Autophagy defends pancreatic β cells from human islet amyloid polypeptide-induced toxicity.The Journal of clinical investigation · 2014Article
- MED12 and HMGA2 mutations: two independent genetic events in uterine leiomyoma and leiomyosarcoma.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2014Article
- Unfolded protein response in hepatitis C virus infection.Frontiers in microbiology · 2014Review
- Tight junction proteins and oxidative stress in heavy metals-induced nephrotoxicity.BioMed research international · 2013Review
- Decursin Isolated from Angelica gigas Nakai Rescues PC12 Cells from Amyloid β-Protein-Induced Neurotoxicity through Nrf2-Mediated Upregulation of Heme Oxygenase-1: Potential Roles of MAPK.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- HIV-1 gp120 induces antioxidant response element-mediated expression in primary astrocytes: role in HIV associated neurocognitive disorder.Neurochemistry international · 2012Article
- Inhibition of nuclear factor erythroid 2-related factor 2 exacerbates HIV-1 gp120-induced oxidative and inflammatory response: role in HIV associated neurocognitive disorder.Neurochemical research · 2012Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
The neuroimmunodegenerative syndrome that develops in mice infected with ts1, a mutant of Moloney murine leukemia virus, resembles human AIDS. Both ts1 and human immunodeficiency virus type 1 infect astrocytes, microglia, and oligodendrocytes but do not infect neurons. Oxidative stress has been implicated in the neuropathology of AIDS dementia and other neurodegenerative diseases. We report here that ts1 infection of astrocytes (both transformed C1 cells and primary cultures) also induces thiol (i.e., glutathione and cysteine) depletion and reactive oxygen species (ROS) accumulation, events occurring in parallel with viral envelope precursor gPr80(env) accumulation and upregulated expression of endoplasmic reticulum chaperones GRP78 and GRP94. Furthermore, ts1-infected astrocytes mobilize their thiol redox defenses by upregulating levels of the Nrf-2 transcription factor, as well its targets, the xCT cystine/glutamate antiporter, gamma-glutamylcysteine ligase, and glutathione peroxidase. Depleting intracellular thiols by treating uninfected astrocytes with buthionine sulfoximine (BSO), a glutathione synthesis inhibitor, or by culturing in cystine-deficient medium, also induces ROS accumulation, activates Nrf-2, and upregulates Nrf-2 target gene expression in these astrocytes. Overexpression of Nrf-2 in astrocytes specifically increases expression of the above thiol synthesis-related proteins. Further treatment with BSO or N-acetylcysteine in transfected cells modulates this expression. Thiol depletion also accelerates cell death, while thiol supplementation promotes survival of ts1-infected cells. Together, our results indicate that ts1 infection of astrocytes, along with ts1-induced gPr80(env) accumulation, endoplasmic reticulum stress, thiol depletion, and oxidative stress, accelerates cell death; in response to the thiol depletion and oxidative stress, astrocytes activate their Nrf-2-mediated thiol antioxidant defenses, promoting cell survival.
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