ArticleJournal of virology2004
Reduction of retrovirus-induced immunosuppression by in vivo modulation of T cells during acute infection.
Article in Journal of virology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 55 citations in OpenAlex.
- Crosstalk of Microorganisms and Immune Responses in Autoimmune Neuroinflammation: A Focus on Regulatory T Cells.Frontiers in immunology · 2021Review
- Friend retrovirus studies reveal complex interactions between intrinsic, innate and adaptive immunity.FEMS microbiology reviews · 2019Review
- Microglia have a protective role in viral encephalitis-induced seizure development and hippocampal damage.Brain, behavior, and immunity · 2018Article
- Regulatory T cells in retroviral infections.PLoS pathogens · 2018Review
- Differential Inhibitory Receptor Expression on T Cells Delineates Functional Capacities in Chronic Viral Infection.Journal of virology · 2017Article
- Theiler's murine encephalomyelitis virus infection of SJL/J and C57BL/6J mice: Models for multiple sclerosis and epilepsy.Journal of neuroimmunology · 2017Review
- Enhanced CD8 T cell responses through GITR-mediated costimulation resolve chronic viral infection.PLoS pathogens · 2015Article
- CD4+ T cells develop antiretroviral cytotoxic activity in the absence of regulatory T cells and CD8+ T cells.Journal of virology · 2013Article
- Targeting the B7 family of co-stimulatory molecules: successes and challenges.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2013Review
- TLR3 signaling is either protective or pathogenic for the development of Theiler's virus-induced demyelinating disease depending on the time of viral infection.Journal of neuroinflammation · 2011Article
- Virus expanded regulatory T cells control disease severity in the Theiler's virus mouse model of MS.Journal of autoimmunity · 2011Article
- Regulatory T cells in infection.Advances in immunology · 2011Review
- Retroviral infection in vivo requires an immune escape virulence factor encrypted in the envelope protein of oncoretroviruses.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Regulatory T cells suppress antiviral immune responses and increase viral loads during acute infection with a lymphotropic retrovirus.PLoS pathogens · 2009Article
- Retroviral immunology: lessons from a mouse model.Immunologic research · 2009Article
- CD137 costimulation of CD8+ T cells confers resistance to suppression by virus-induced regulatory T cells.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Suppression of acute anti-friend virus CD8+ T-cell responses by coinfection with lactate dehydrogenase-elevating virus.Journal of virology · 2008Article
- Regulatory T cells and infection: a dangerous necessity.Nature reviews. Immunology · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Chronic infection with Friend retrovirus is associated with suppressed antitumor immune responses. In the present study we investigated whether modulation of T-cell responses during acute infection would restore antitumor immunity in persistently infected mice. T-cell modulation was done by treatments with DTA-1 anti- glucocorticoid-induced tumor necrosis factor receptor monoclonal antibodies. The DTA-1 monoclonal antibody is nondepleting and delivers costimulatory signals that both enhance the activation of effector T cells and inhibit suppression by regulatory T cells. DTA-1 therapy produced faster Th1 immune responses, significant reductions in both acute virus loads and pathology and, most importantly, long-term improvement of CD8(+) T-cell-mediated antitumor responses.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.