ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2004
Smooth muscle hypertrophy in distal airways of sensitized infant rhesus monkeys exposed to house dust mite allergen.
Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 39 citations in OpenAlex.
- Organized lymphatic tissue (BALT) in lungs of rhesus monkeys after air pollutant exposure.Anatomical record (Hoboken, N.J. : 2007) · 2020Review
- Airway remodeling in asthma: what really matters.Cell and tissue research · 2017Review
- Early life exposure to allergen and ozone results in altered development in adolescent rhesus macaque lungs.Toxicology and applied pharmacology · 2015Article
- Anti-inflammatory dimethylfumarate: a potential new therapy for asthma?Mediators of inflammation · 2013Review
- Lung effects of inhaled corticosteroids in a rhesus monkey model of childhood asthma.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2012Article
- Is there a regulatory role of immunoglobulins on tissue forming cells relevant in chronic inflammatory lung diseases?Journal of allergy · 2011Article
- An inhalation model of airway allergic response to inhalation of environmental Aspergillus fumigatus conidia in sensitized BALB/c mice.Medical mycology · 2010Article
- Impact of environmental chemicals on lung development.Environmental health perspectives · 2010Review
- Airway mast cells in a rhesus model of childhood allergic airways disease.Toxicological sciences : an official journal of the Society of Toxicology · 2010Article
- In utero and postnatal exposure to arsenic alters pulmonary structure and function.Toxicology and applied pharmacology · 2009Article
- Allergen-induced airway remodelling.The European respiratory journal · 2007Review
- Mite immunotherapy.Current allergy and asthma reports · 2006Review
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAirway smooth muscle hypertrophy is closely associated with the pathophysiology of hyper-reactive airways in allergic asthma.
objectiveTo determine whether repeated exposure to allergens during postnatal lung development promotes remodelling of airway smooth muscle.
methodsInfant, male rhesus monkeys (30-day-old) were sensitized to house dust mite allergen (HDMA) and then exposed to HDMA aerosol periodically over 5 months. Smooth muscle mass and bundle size and abundance in conducting airways were measured and compared with age-matched control (filtered air-exposed) monkeys.
resultsTotal smooth muscle mass and average bundle size were significantly greater in the conducting airways of monkeys exposed to HDMA. Smooth muscle bundle abundance was not affected by exposure to HDMA.
conclusionRepeated cycles of allergen exposure alter postnatal morphogenesis of smooth muscle, affecting both total mass and bundle size, in conducting airways of infant monkeys.
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