ReviewImmunologic research2004
The role of LIGHT in T cell-mediated immunity.
Review in Immunologic research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Tumor Necrosis Factor Superfamily 14: A Potential Predictor of Atrial Fibrillation Recurrence After Catheter Ablation.Clinical cardiology · 2026Article
- TNFSF14 (LIGHT) in intestinal inflammation: balancing immune activation and resolution in IBD.Frontiers in immunology · 2025Review
- LIGHT (TNFSF14) promotes the differentiation of human bone marrow-derived mesenchymal stem cells into functional hepatocyte-like cells.PloS one · 2023Article
- T cell co-stimulatory and co-inhibitory pathways in atopic dermatitis.Frontiers in immunology · 2023Review
- Immune system-wide Mendelian randomization and triangulation analyses support autoimmunity as a modifiable component in dementia-causing diseases.Nature aging · 2022Article
- Realigning the LIGHT signaling network to control dysregulated inflammation.The Journal of experimental medicine · 2022Article
- New insights into immunomodulatory properties of lactic acid bacteria fermented herbal medicines.Frontiers in microbiology · 2022Review
- LIGHT (TNFSF14) enhances osteogenesis of human bone marrow-derived mesenchymal stem cells.PloS one · 2021Article
- Article
- Lymphotoxin β receptor-mediated NFκB signaling promotes glial lineage differentiation and inhibits neuronal lineage differentiation in mouse brain neural stem/progenitor cells.Journal of neuroinflammation · 2018Article
- Genetic variations in LIGHT are associated with susceptibility to ankylosing spondylitis in a Chinese Han population.Oncotarget · 2017Article
- LIGHT (TNFSF14) Increases the Survival and Proliferation of Human Bone Marrow-Derived Mesenchymal Stem Cells.PloS one · 2016Article
- Temporal protein expression pattern in intracellular signalling cascade during T-cell activation: a computational study.Journal of biosciences · 2015Article
- Real-time imaging reveals the dynamics of leukocyte behaviour during experimental cerebral malaria pathogenesis.PLoS pathogens · 2014Article
- Glatiramer acetate treatment effects on gene expression in monocytes of multiple sclerosis patients.Journal of neuroinflammation · 2013Article
- T cell co-stimulatory molecules: a co-conspirator in the pathogenesis of eosinophilic esophagitis?Digestive diseases and sciences · 2013Review
- Autoimmune therapies targeting costimulation and emerging trends in multivalent therapeutics.Therapeutic delivery · 2011Review
- Chemokine expression in melanoma metastases associated with CD8+ T-cell recruitment.Cancer research · 2009Article
- NK-cell activation by LIGHT triggers tumor-specific CD8+ T-cell immunity to reject established tumors.Blood · 2006Article
- Circulating soluble LIGHT/TNFSF14 is increased and associated with IL-8 concentration in chronic spontaneous urticaria.International journal of immunopathology and pharmacologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
This review focuses on the role of homologous to lymphotoxin, exhibits inducible expression, competes with herpesvirus glycoprotein D for HVEM on T cells (LIGHT) in T-cell immunity and T cell-mediated diseases. LIGHT binds to lymphotoxin-beta receptor (LTbetaR), and cooperates with LTbeta in lymphoid organogenesis and development of lymphoid structure. Previous findings establish a crucial biological role for LIGHT, a T cell-derived costimulatory ligand, in T-cell activation and expansion via a T-T cell-dependent manner. Transgenic studies demonstrated that the dysregulation of LIGHT activity results in the disturbance of T-cell homeostasis and ultimately the breakdown of peripheral tolerance. Furthermore, the blockade of LIGHT activity ameliorates the severity of T cell-mediated diseases indicating the essential involvement of LIGHT in various pathological conditions. Here, we review the recent studies about LIGHT mainly in the context of autoimmunity and conclude with a discussion of the potential mechanisms by which LIGHT promotes autoimmunity.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.