Evidence map›Paper›PMID 15477658›Full record

ReviewImmunologic research2004

Association of intracellular proteins with folded major histocompatibility complex class I molecules.

Chantey R Morris, Adrian J Reber, Jason L Petersen, Shanna E Vargas, Joyce C Solheim

Abstract readReview
PubMed Publisher
In one paragraph

Review in Immunologic research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chantey R MorrisEppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198-6805, USA.
Adrian J Reber
Jason L Petersen
Shanna E Vargas
Joyce C Solheim

Funding

CHEMICAL CARCINOGENESIS &CANCER BIOLOGYT32CA009476 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Jennifer D. Black · 1988 to 2026
$6.2M
ER PROTEINS EFFECT ON CLASS I MHC ASSEMBLYR01GM057428 · NIGMS · UNIVERSITY OF SOUTH DAKOTA · PI SOLHEIM, JOYCE C · 1998 to 2009
$1.5M
Regulation of Antigen Presentation by APLP-2R21AI054645 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI SOLHEIM, JOYCE C · 2004 to 2005
$368k
Regulation of Antigen Presentation by APLP-2F32AI055152 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI MORRIS, CHANTEY R · 2003 to 2004
$95k
Tapasin Regulation of Epitope PresentationF32AI056811 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI PETERSEN, JASON L · 2003 to 2004
$65k
NCI NIH HHS T32 CA09476NIAID NIH HHS F32 AI055152NIAID NIH HHS F32 AI056811NIAID NIH HHS R21 AI54645NIGMS NIH HHS R01 GM57428
6 · The paper itself

Abstract

The major histocompatibility complex (MHC) class I molecule is responsible for presenting peptide antigens at the cell surface for recognition by cytotoxic T lymphocytes. Several chaperone molecules interact with the MHC class I heavy chain and release when the MHC groove folds around peptide. Two additional proteins, invariant chain and amyloid precursor-like protein 2 (APLP2), interact specifically and stably with MHC class I molecules that have folded peptide-binding grooves. Invariant chain and APLP2 also affect MHC class I cell-surface expression, and so may play a part in MHC class I trafficking. Association of APLP2 with the MHC class I molecule appears to be regulated by a viral protein, the adenovirus E3/19K protein. Analysis of the interactions of these proteins with each other and with MHC class I will clarify how presentation of antigens by MHC class I is controlled by events that occur subsequent to MHC class I folding.

Indexed as

AdenoviridaeAdenovirus E3 ProteinsAmyloid beta-Protein PrecursorAnimalsAntigen PresentationAntigen-Presenting CellsHistocompatibility Antigens Class IHumansMiceNerve Tissue ProteinsProtein FoldingT-Lymphocytes, CytotoxicAdenovirus E3 ProteinsAmyloid beta-Protein PrecursorAPLP2 protein, humanAplp2 protein, mouseHistocompatibility Antigens Class INerve Tissue Proteins

Identifiers

PMID15477658

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.