ArticleOccupational and environmental medicine2004
Decreased fecundity among male lead workers.
Article in Occupational and environmental medicine, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 65 citations in OpenAlex.
- Occupational Exposure to Physical and Chemical Risk Factors: A Systematic Review of Reproductive Pathophysiological Effects in Women and Men.Safety and health at work · 2023Review
- The Impact of the Flint Water Crisis on Fertility.Demography · 2019Article
- [Exposure of man to metal trace elements and alteration of sperm parameters: study conducted in the mining areas of Haut-Katanga in the Democratic Republic of Congo].The Pan African medical journal · 2018Article
- Paternal exposures to environmental chemicals and time-to-pregnancy: overview of results from the LIFE study.Andrology · 2016Article
- Heavy metals and couple fecundity, the LIFE Study.Chemosphere · 2012Article
- How does lead induce male infertility?Iranian journal of reproductive medicine · 2011Review
- Male reproductive organs are at risk from environmental hazards.Asian journal of andrology · 2010Review
- Exposure to a mixture of polychlorinated biphenyls and polychlorinated dibenzofurans resulted in a prolonged time to pregnancy in women.Environmental health perspectives · 2008Article
- Radiofrequency electromagnetic fields; male infertility and sex ratio of offspring.European journal of epidemiology · 2008Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo investigate time to pregnancy (TTP) in male lead workers in order to determine the dose-response relation between blood lead and decreased fecundity.
methodsA total of 163 currently employed married male lead battery workers were classified into five categories of exposure based on questionnaire information and annual individual blood lead measurement. Information pertaining to the TTP was collected using personal interviews with 133 men and their spouses, with 280 valid pregnancies. The fecundability ratios (FRs) were calculated with the Cox discrete proportional hazard regression technique to evaluate the effects of lead exposure.
resultsAfter other factors associated with TTP were controlled for, there was a dose-response relation between blood lead level and TTP. The measured FRs were 0.90 (95% CI 0.61 to 1.34), 0.72 (0.46 to 1.11), 0.52 (0.35 to 0.77), and 0.40 (0.27 to 0.59) for concurrent blood lead levels of <20, 20-29, 30-39, and > or =40 microg/dl, respectively. Paired self comparison was also performed for 41 couples that had pregnancies prior to lead exposure and pregnancies with male occupational lead exposure. The TTP was prolonged for 0.15 cycles by a 1 microg/dl increase in blood lead.
conclusionsThese results corroborate the hypothesis that a raised blood lead level affects fecundity. A blood lead level of less than 40 microg/dl may still significantly prolong TTP.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.