ReviewMolecular neurobiology2004
The physiological role of kainate receptors in the amygdala.
Review in Molecular neurobiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Role of the Amygdala in the Complex Relationship Between Sleep and Anxiety.International journal of molecular sciences · 2026Review
- α-linolenic acid-induced facilitation of GABAergic synaptic transmission is mediated via acid-sensing ion channel (ASIC1a) activity in the basolateral amygdala.Experimental biology and medicine (Maywood, N.J.) · 2025Article
- The Role of Glutamate Receptors in Epilepsy.Biomedicines · 2023Review
- Repeated shock stress facilitates basolateral amygdala synaptic plasticity through decreased cAMP-specific phosphodiesterase type IV (PDE4) expression.Brain structure & function · 2018Article
- Basolateral amygdala and stress-induced hyperexcitability affect motivated behaviors and addiction.Translational psychiatry · 2017Review
- Cortical kainate receptors and behavioral anxiety.Molecular brain · 2017Review
- The basolateral amygdala γ-aminobutyric acidergic system in health and disease.Journal of neuroscience research · 2016Review
- Bidirectional regulation of synaptic plasticity in the basolateral amygdala induced by the D1-like family of dopamine receptors and group II metabotropic glutamate receptors.The Journal of physiology · 2014Article
- Mitochondrial Gene Expression Profiles and Metabolic Pathways in the Amygdala Associated with Exaggerated Fear in an Animal Model of PTSD.Frontiers in neurology · 2014Article
- Ethanol modulation of synaptic plasticity.Neuropharmacology · 2011Review
- Synergistic activation of dopamine D1 and TrkB receptors mediate gain control of synaptic plasticity in the basolateral amygdala.PloS one · 2011Article
- Arterial spin labeling demonstrates that focal amygdalar glutamatergic agonist infusion leads to rapid diffuse cerebral activation.Acta neurologica Scandinavica · 2010Article
- Glutamate plasticity in the drunken amygdala: the making of an anxious synapse.International review of neurobiology · 2010Review
- Pathological alterations in GABAergic interneurons and reduced tonic inhibition in the basolateral amygdala during epileptogenesis.Neuroscience · 2009Article
- Primary brain targets of nerve agents: the role of the amygdala in comparison to the hippocampus.Neurotoxicology · 2009Article
- Transcriptional and electrophysiological maturation of neocortical fast-spiking GABAergic interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Soman induces ictogenesis in the amygdala and interictal activity in the hippocampus that are blocked by a GluR5 kainate receptor antagonist in vitro.Neuroscience · 2009Article
- Ethanol inhibition of kainate receptor-mediated excitatory neurotransmission in the rat basolateral nucleus of the amygdala.Neuropharmacology · 2008Article
- Evidence for the involvement of the kainate receptor subunit GluR6 (GRIK2) in mediating behavioral displays related to behavioral symptoms of mania.Molecular psychiatry · 2008Article
- Ionotropic glutamate receptors & CNS disorders.CNS & neurological disorders drug targets · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The kainate subtype of glutamate receptors has received considerable attention in recent years, and a wealth of knowledge has been obtained regarding the function of these receptors. Kainate receptors have been shown to mediate synaptic transmission in some brain regions, modulate presynaptic release of glutamate and gamma-aminobutyric acid (GABA), and mediate synaptic plasticity or the development of seizure activity. This article focuses on the function of kainate receptors in the amygdala, a brain region that plays a central role in emotional behavior and certain psychiatric illnesses. Evidence is reviewed indicating that postsynaptic kainate receptors containing the glutamate receptor 5 kainate receptor (GLUk5) subunit are present on interneurons and pyramidal cells in the basolateral amygdala and mediate a component of the synaptic responses of these neurons to glutamatergic input. In addition, GLUk5-containing kainate receptors are present on presynaptic terminals of GABAergic neurons, where they modulate the release of GABA in an agonist concentration-dependent, bidirectional manner. GLUk5-containing kainate receptors also mediate a longlasting synaptic facilitation induced by low-frequency stimulation in the external capsule to the basolateral nucleus pathway, and they appear to be partly responsible for the susceptibility of the amygdala to epileptogenesis. Taken together, these findings have suggested a prominent role of GLUk5-containing kainate receptors in the regulation of neuronal excitability in the amygdala.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.