ArticleBiophysical journal2005
Lateral diffusion of PEG-Lipid in magnetically aligned bicelles measured using stimulated echo pulsed field gradient 1H NMR.
Article in Biophysical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 48 citations in OpenAlex.
- Article
- When detergent meets bilayer: birth and coming of age of lipid bicelles.Progress in nuclear magnetic resonance spectroscopy · 2013Review
- Structural Versatility of Bicellar Systems and Their Possibilities as Colloidal Carriers.Pharmaceutics · 2011Article
- Concentration dependence of lipopolymer self-diffusion in supported bilayer membranes.Journal of the Royal Society, Interface · 2011Article
- Size of bicelle defects probed via diffusion nuclear magnetic resonance of PEG.Biophysical journal · 2009Article
- Comprehensive analysis of lipid dynamics variation with lipid composition and hydration of bicelles using nuclear magnetic resonance (NMR) spectroscopy.Langmuir : the ACS journal of surfaces and colloids · 2009Article
- Bicelles: A natural 'molecular goniometer' for structural, dynamical and topological studies of molecules in membranes.Biochimie · 2009Review
- Effects on interactions of oppositely charged phospholipid vesicles of covalent attachment of polyethylene glycol oligomers to their surfaces: adhesion, hemifusion, full fusion and "endocytosis".The Journal of membrane biology · 2008Article
- Effects of lipid chain length and unsaturation on bicelles stability. A phosphorus NMR study.Biophysical journal · 2006Article
- Supported lipopolymer membranes as nanoscale filters: simultaneous protein recognition and size-selection assays.Journal of the American Chemical Society · 2006Article
- Thin liquid films and monolayers of DMPC mixed with PEG and phospholipid linked PEG.European biophysics journal : EBJ · 2006Article
- Influence of the long-chain/short-chain amphiphile ratio on lateral diffusion of PEG-lipid in magnetically aligned lipid bilayers as measured via pulsed-field-gradient NMR.Biophysical journal · 2005Article
- "Bicellar" lipid mixtures as used in biochemical and biophysical studies.Die Naturwissenschaften · 2005Article
- Reinvestigation by phosphorus NMR of lipid distribution in bicelles.Biophysical journal · 2005Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lateral diffusion measurements of PEG-lipid incorporated into magnetically aligned bicelles are demonstrated using stimulated echo (STE) pulsed field gradient (PFG) proton (1H) nuclear magnetic resonance (NMR) spectroscopy. Bicelles were composed of dimyristoyl phosphatidylcholine (DMPC) plus dihexanoyl phosphatidylcholine (DHPC) (q = DMPC/DHPC molar ratio = 4.5) plus 1 mol % (relative to DMPC) dimyristoyl phosphatidylethanolamine-N-[methoxy(polyethylene glycol)-2000] (DMPE-PEG 2000) at 25 wt % lipid. 1H NMR STE spectra of perpendicular aligned bicelles contained only resonances assigned to residual HDO and to overlapping contributions from a DMPE-PEG 2000 ethoxy headgroup plus DHPC choline methyl protons. Decay of the latter's STE intensity in the STE PFG 1H NMR experiment (g(z) = 244 G cm(-1)) yielded a DMPE-PEG 2000 (1 mol %, 35 degrees C) lateral diffusion coefficient D = 1.35 x 10(-11) m2 s(-1). Hence, below the "mushroom-to-brush" transition, DMPE-PEG 2000 lateral diffusion is dictated by its DMPE hydrophobic anchor. D was independent of the diffusion time, indicating unrestricted lateral diffusion over root mean-square diffusion distances of microns, supporting the "perforated lamellae" model of bicelle structure under these conditions. Overall, the results demonstrate the feasibility of lateral diffusion measurements in magnetically aligned bicelles using the STE PFG NMR technique.
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