SynthesisJournal of clinical microbiology2004
Large-scale comparative genomics meta-analysis of Campylobacter jejuni isolates reveals low level of genome plasticity.
Synthesis in Journal of clinical microbiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed.
- Differential Distribution of theMicroorganisms · 2020Article
- Horizontal genetic exchange of chromosomally encoded markers between Campylobacter jejuni cells.PloS one · 2020Article
- TheFrontiers in microbiology · 2016Article
- Genetic diversity and antimicrobial susceptibility of Campylobacter jejuni isolates associated with sheep abortion in the United States and Great Britain.Journal of clinical microbiology · 2014Article
- Comprehensive proteomic profiling of outer membrane vesicles from Campylobacter jejuni.Journal of proteomics · 2014Article
- Comparative variation within the genome of Campylobacter jejuni NCTC 11168 in human and murine hosts.PloS one · 2014Article
- Article
- Effects of the Campylobacter jejuni CJIE1 prophage homologs on adherence and invasion in culture, patient symptoms, and source of infection.BMC microbiology · 2012Article
- Phenotypic and genotypic characterizations of Campylobacter jejuni isolated from the broiler meat production process.Current microbiology · 2012Article
- A Gene-By-Gene Approach to Bacterial Population Genomics: Whole Genome MLST of Campylobacter.Genes · 2012Article
- Development and validation of a comparative genomic fingerprinting method for high-resolution genotyping of Campylobacter jejuni.Journal of clinical microbiology · 2012Article
- Comparison of molecular typing methods useful for detecting clusters of Campylobacter jejuni and C. coli isolates through routine surveillance.Journal of clinical microbiology · 2012Article
- Genomic variations define divergence of water/wildlife-associated Campylobacter jejuni niche specialists from common clonal complexes.Environmental microbiology · 2011Article
- Comparison of genotypes of Salmonella enterica serovar Enteritidis phage type 30 and 9c strains isolated during three outbreaks associated with raw almonds.Applied and environmental microbiology · 2010Article
- Advances in Campylobacter biology and implications for biotechnological applications.Microbial biotechnology · 2010Review
- Expanded multilocus sequence typing and comparative genomic hybridization of Campylobacter coli isolates from multiple hosts.Applied and environmental microbiology · 2010Article
- Functional characterization of flagellin glycosylation in Campylobacter jejuni 81-176.Journal of bacteriology · 2009Article
- A DNase encoded by integrated element CJIE1 inhibits natural transformation of Campylobacter jejuni.Journal of bacteriology · 2009Article
- Comparative studies of Campylobacter jejuni genomic diversity reveal the importance of core and dispensable genes in the biology of this enigmatic food-borne pathogen.Current opinion in biotechnology · 2009Article
- Multiple factors interact to produce responses resembling spectrum of human disease in Campylobacter jejuni infected C57BL/6 IL-10-/- mice.BMC microbiology · 2009Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have used comparative genomic hybridization (CGH) on a full-genome Campylobacter jejuni microarray to examine genome-wide gene conservation patterns among 51 strains isolated from food and clinical sources. These data have been integrated with data from three previous C. jejuni CGH studies to perform a meta-analysis that included 97 strains from the four separate data sets. Although many genes were found to be divergent across multiple strains (n = 350), many genes (n = 249) were uniquely variable in single strains. Thus, the strains in each data set comprise strains with a unique genetic diversity not found in the strains in the other data sets. Despite the large increase in the collective number of variable C. jejuni genes (n = 599) found in the meta-analysis data set, nearly half of these (n = 276) mapped to previously defined variable loci, and it therefore appears that large regions of the C. jejuni genome are genetically stable. A detailed analysis of the microarray data revealed that divergent genes could be differentiated on the basis of the amplitudes of their differential microarray signals. Of 599 variable genes, 122 could be classified as highly divergent on the basis of CGH data. Nearly all highly divergent genes (117 of 122) had divergent neighbors and showed high levels of intraspecies variability. The approach outlined here has enabled us to distinguish global trends of gene conservation in C. jejuni and has enabled us to define this group of genes as a robust set of variable markers that can become the cornerstone of a new generation of genotyping methods that use genome-wide C. jejuni gene variability data.
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