ArticleGenes and immunity2004
Interleukin-1beta polymorphisms in Colombian patients with autoimmune rheumatic diseases.
Article in Genes and immunity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Pro-inflammatory cytokine response pre-dominates immuno-genetic pathway in development of rheumatoid arthritis.Molecular biology reports · 2020Pooled it
- A prospective open-label pilot study of fluvastatin on proinflammatory and prothrombotic biomarkers in antiphospholipid antibody positive patients.Annals of the rheumatic diseases · 2014Trial
- Association betweenFrontiers in immunology · 2026Article
- Article
- Pharmacogenomics of Monoclonal Antibodies for the Treatment of Rheumatoid Arthritis.Journal of personalized medicine · 2022Review
- Proinflammatory Cytokines (IL-1, -6, -8, -15, -17, -18, -23, TNF-α) Single Nucleotide Polymorphisms in Rheumatoid Arthritis-A Literature Review.International journal of molecular sciences · 2022Review
- An interleukin-1 polymorphism additionally intensified by atopy as prognostic factor for aseptic non-mechanical complications in metal knee and hip arthroplasty.Frontiers in immunology · 2022Article
- Differential expression of the inflammasome complex genes in systemic lupus erythematosus.Immunogenetics · 2020Article
- Genetic Susceptibility to Antisynthetase Syndrome Associated With Single-Nucleotide Variants in theFrontiers in medicine · 2020Article
- Polymorphisms of cytokine genes and tuberculosis in two independent studies.Scientific reports · 2019Article
- The Potential Role of Trained Immunity in Autoimmune and Autoinflammatory Disorders.Frontiers in immunology · 2018Review
- Genetic Polymorphisms ofBioMed research international · 2018Article
- Article
- Variants in LTA, TNF, IL1B and IL10 genes associated with the clinical course of sepsis.Immunologic research · 2016Article
- Article
- Interleukin-1 as a common denominator from autoinflammatory to autoimmune disorders: premises, perils, and perspectives.Mediators of inflammation · 2015Review
- Interleukin-1 gene cluster and IL-1 receptor polymorphisms in Iranian patients with systemic lupus erythematosus.Rheumatology international · 2013Article
- Common and specific signatures of gene expression and protein-protein interactions in autoimmune diseases.Genes and immunity · 2013Article
- Genetic risk factors of systemic lupus erythematosus in the Malaysian population: a minireview.Clinical & developmental immunology · 2012Review
- Genetic variants in inflammation pathway genes and asthma in glioma susceptibility.Neuro-oncology · 2010Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interleukin-1 beta (IL-1beta) exerts a range of inflammatory and immunomodulatory activities that are important in host defense and autoimmune response. The IL-1beta gene, located on chromosome 2 (2q13), is polymorphic. The influence of its polymorphism on 355 patients with autoimmune rheumatic diseases was examined. To this effect, 172 patients with rheumatoid arthritis (RA), 114 with systemic lupus erythematosus (SLE), and 69 with primary Sjogren's syndrome (pSS) were studied. The control group consisted of 392 matched healthy individuals. Genotyping of IL-1beta single-nucleotide polymorphisms (SNPs) at positions -511 (C/T) and + 3953 (C/T) was performed by the polymerase chain reaction-restriction fragment length polymorphism technique. In addition, levels of IL-1beta were measured by immunoassay in supernatants of lipopolysaccharide (LPS)-stimulated and nonstimulated peripheral blood monocytes (PBM) obtained from 19 homozygous individuals for the three most common IL-1beta likely haplotypes, all belonging to the control group. Allele + 3953T was protective for SLE (odds ratio (OR) = 0.57, 95% confidence intervals (CI) = 0.34-0.88, P = 0.01) as was the haplotype -511C + 3953T (OR = 0.43, 95%CI = 0.25-0.74, pc = 0.006). The latter was associated with a lower LPS-stimulated-PBM IL-1beta secretion. Results suggest that IL-1beta polymorphism influences the susceptibility to acquire SLE in our population. The protective association might be explained by the observed inhibitory effect of IL-1beta + 3953T allele on the secretion of IL-1beta under inflammatory circumstances.
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