ArticleEukaryotic cell2004
Control of cell type proportioning in Dictyostelium discoideum by differentiation-inducing factor as determined by in situ hybridization.
Article in Eukaryotic cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- Global profiling of polyketide synthases in facultative multicellular eukaryotes.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Transition state dynamics during a stochastic fate choice.Development (Cambridge, England) · 2019Article
- Implications of expansin-like 3 gene in Dictyostelium morphogenesis.SpringerPlus · 2015Article
- Article
- Systematic analysis of γ-aminobutyric acid (GABA) metabolism and function in the social amoeba Dictyostelium discoideum.The Journal of biological chemistry · 2013Article
- Mef2A, a homologue of animal Mef2 transcription factors, regulates cell differentiation in Dictyostelium discoideum.BMC developmental biology · 2013Article
- One stop shop for everything Dictyostelium: dictyBase and the Dicty Stock Center in 2012.Methods in molecular biology (Clifton, N.J.) · 2013Article
- Cell type-specific filamin complex regulation by a novel class of HECT ubiquitin ligase is required for normal cell motility and patterning.Development (Cambridge, England) · 2011Article
- Forming patterns in development without morphogen gradients: scattered differentiation and sorting out.Cold Spring Harbor perspectives in biology · 2009Review
- Acidic Ca2+ stores, excitability, and cell patterning in Dictyostelium discoideum.Eukaryotic cell · 2009Review
- Regulation of Rap1 activity is required for differential adhesion, cell-type patterning and morphogenesis in Dictyostelium.Journal of cell science · 2009Article
- DIF-1 induces the basal disc of the Dictyostelium fruiting body.Developmental biology · 2008Article
- Cell type specificity of a diffusible inducer is determined by a GATA family transcription factor.Development (Cambridge, England) · 2008Article
- GBF-dependent family genes morphologically suppress the partially active Dictyostelium STATa strain.Development genes and evolution · 2008Article
- Treasure hunt in an amoeba: non-coding RNAs in Dictyostelium discoideum.Current genetics · 2007Review
- bZIP transcription factor interactions regulate DIF responses in Dictyostelium.Development (Cambridge, England) · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
We have determined the proportions of the prespore and prestalk regions in Dictyostelium discoideum slugs by in situ hybridization with a large number of prespore- and prestalk-specific genes. Microarrays were used to discover genes expressed in a cell type-specific manner. Fifty-four prespore-specific genes were verified by in situ hybridization, including 18 that had been previously shown to be cell type specific. The 36 new genes more than doubles the number of available prespore markers. At the slug stage, the prespore genes hybridized to cells uniformly in the posterior 80% of wild-type slugs but hybridized to the posterior 90% of slugs lacking the secreted alkylphenone differentiation-inducing factor 1 (DIF-1). There was a compensatory twofold decrease in prestalk cells in DIF-less slugs. Removal of prespore cells resulted in cell type conversion in both wild-type and DIF-less anterior fragments. Thus, DIF-1 appears to act in concert with other processes to establish cell type proportions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.