ArticleEukaryotic cell2004
Nucleus-encoded genes for plastid-targeted proteins in Helicosporidium: functional diversity of a cryptic plastid in a parasitic alga.
Article in Eukaryotic cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 46 citations in OpenAlex.
- Reduced plastid genomes of colorless facultative pathogens Prototheca (Chlorophyta) are retained for membrane transport genes.BMC biology · 2024Article
- Components of iron-Sulfur cluster assembly machineries are robust phylogenetic markers to trace the origin of mitochondria and plastids.PLoS biology · 2023Article
- Taxonomic scheme of the order Chaetophorales (Chlorophyceae, Chlorophyta) based on chloroplast genomes.BMC genomics · 2020Article
- Comparative Plastid Genomics of Non-Photosynthetic Chrysophytes: Genome Reduction and Compaction.Frontiers in plant science · 2020Article
- Comparative analysis of nucleus-encoded plastid-targeting proteins in Rafflesia cantleyi against photosynthetic and non-photosynthetic representatives reveals orthologous systems with potentially divergent functions.Scientific reports · 2018Article
- Reductive evolution of chloroplasts in non-photosynthetic plants, algae and protists.Current genetics · 2018Review
- What was the real contribution of endosymbionts to the eukaryotic nucleus? Insights from photosynthetic eukaryotes.Cold Spring Harbor perspectives in biology · 2014Review
- A plastid without a genome: evidence from the nonphotosynthetic green algal genus Polytomella.Plant physiology · 2014Article
- Article
- Mechanisms of functional and physical genome reduction in photosynthetic and nonphotosynthetic parasitic plants of the broomrape family.The Plant cell · 2013Article
- The Non-Photosynthetic Algae Helicosporidium spp.: Emergence of a Novel Group of Insect Pathogens.Insects · 2013Review
- Article
- The endosymbiotic origin, diversification and fate of plastids.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
- Article
- On the origin of chloroplasts, import mechanisms of chloroplast-targeted proteins, and loss of photosynthetic ability - review.Folia microbiologica · 2009Review
- TBestDB: a taxonomically broad database of expressed sequence tags (ESTs).Nucleic acids research · 2007Article
- The complete plastid genome sequence of the parasitic green alga Helicosporidium sp. is highly reduced and structured.BMC biology · 2006Article
- Enzymes of the heme biosynthetic pathway in the nonphotosynthetic alga Polytomella sp.Eukaryotic cell · 2005Article
- Multiple metabolic roles for the nonphotosynthetic plastid of the green alga Prototheca wickerhamii.Eukaryotic cell · 2005Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plastids are the organelles of plants and algae that house photosynthesis and many other biochemical pathways. Plastids contain a small genome, but most of their proteins are encoded in the nucleus and posttranslationally targeted to the organelle. When plants and algae lose photosynthesis, they virtually always retain a highly reduced "cryptic" plastid. Cryptic plastids are known to exist in many organisms, although their metabolic functions are seldom understood. The best-studied example of a cryptic plastid is from the intracellular malaria parasite, Plasmodium, which has retained a plastid for the biosynthesis of fatty acids, isoprenoids, and heme by the use of plastid-targeted enzymes. To study a completely independent transformation of a photosynthetic plastid to a cryptic plastid in another alga-turned-parasite, we conducted an expressed sequence tag (EST) survey of Helicosporidium. This parasite has recently been recognized as a highly derived green alga. Based on phylogenetic relationships to other plastid homologues and the presence of N-terminal transit peptides, we have identified 20 putatively plastid-targeted enzymes that are involved in a wide variety of metabolic pathways. Overall, the metabolic diversity of the Helicosporidium cryptic plastid exceeds that of the Plasmodium plastid, as it includes representatives of most of the pathways known to operate in the Plasmodium plastid as well as many others. In particular, several amino acid biosynthetic pathways have been retained, including the leucine biosynthesis pathway, which was only recently recognized in plant plastids. These two parasites represent different evolutionary trajectories in plastid metabolic adaptation.
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