ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
A new platform to study the molecular mechanisms of exocytosis.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Dynamic regulation of vesicle pools in a detailed spatial model of the complete synaptic vesicle cycle.Science advances · 2025Article
- Bayesian inference for parameter estimation in lactoferrin-mediated iron transport across blood-brain barrier.Biochimica et biophysica acta. General subjects · 2020Article
- Iron transport kinetics through blood-brain barrier endothelial cells.Biochimica et biophysica acta. General subjects · 2018Article
- Dynamical Organization of Syntaxin-1A at the Presynaptic Active Zone.PLoS computational biology · 2015Article
- Super-resolution imaging reveals the internal architecture of nano-sized syntaxin clusters.The Journal of biological chemistry · 2012Article
- Network motif comparison rationalizes Sec1/Munc18-SNARE regulation mechanism in exocytosis.BMC systems biology · 2012Article
- A computational analysis framework for molecular cell dynamics: case-study of exocytosis.PloS one · 2012Article
- Friends and foes in synaptic transmission: the role of tomosyn in vesicle priming.Trends in neurosciences · 2009Review
- Vesicle priming and recruitment by ubMunc13-2 are differentially regulated by calcium and calmodulin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
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Authors and funding
4 authors.
Funding
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Abstract
The exocytotic process in neurons and neuroendocrine cells consists of a sequence of reactions between well defined proteins. In the present study, we have created for the first time a comprehensive kinetic model that demonstrates the dynamics of interactions between key synaptic proteins that are associated with exocytosis. The interactions between the synaptic proteins were transformed into differential rate equations that, after their integration over time, reconstructed the experimental signal. The model can perfectly reconstruct the kinetics of exocytosis, the calcium-dependent priming and fusion processes, and the effects of genetic manipulation of synaptic proteins. The model suggests that fusion occurs from two parallel pathways and assigns precise, non-identical synaptic protein complexes to the two pathways. In addition, it provides a unique opportunity to study the dynamics of intermediate protein complexes during the fusion process, a possibility that is hidden in most experimental systems. We thus developed a novel approach that allows detailed characterization of the temporal relationship between synaptic protein complexes. This model provides an excellent platform for prediction and quantification of the effects of protein manipulations on exocytosis and opens new avenues for experimental investigation of exocytosis.
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Registered trials
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