ArticleProceedings of the National Academy of Sciences of the United States of America2004
Ciona intestinalis Hox gene cluster: Its dispersed structure and residual colinear expression in development.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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75 citing papers in PubMed, 205 citations in OpenAlex.
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- The dorsal/ventral subdivision of the hindbrain predates the tunicate/vertebrate split.bioRxiv : the preprint server for biology · 2025Article
- The application of irreversible genomic states to define and trace ancient cell type homologies.EvoDevo · 2025Article
- Identification of Six Novel Proteins Containing a ZP Module from Nemertean Species.Biomolecules · 2024Article
- Evolutionary plasticity in nematode Hox gene complements and genomic loci arrangement.Scientific reports · 2024Article
- Single-cell Transcriptomic Studies Unveil Potential Nodes of the Notochord Gene Regulatory Network.Integrative and comparative biology · 2024Review
- High-resolution chromosome-level genome of Scylla paramamosain provides molecular insights into adaptive evolution in crabs.BMC biology · 2024Article
- Repetitive and zonal expression profiles of absorption-related genes in the gastrointestinal tract of ascidian Ciona intestinalis type A.Cell and tissue research · 2023Article
- Sinus venosus adaptation models prolonged cardiovascular disease and reveals insights into evolutionary transitions of the vertebrate heart.Nature communications · 2023Article
- Comparative Transcriptomic Analysis Reveals the Functionally Segmented Intestine in Tunicate Ascidian.International journal of molecular sciences · 2023Article
- Echiuran Hox genes provide new insights into the correspondence between Hox subcluster organization and collinearity pattern.Proceedings. Biological sciences · 2022Article
- A mosaic of conserved and novel modes of gene expression and morphogenesis in mesoderm and muscle formation of a larval bivalve.Organisms, diversity & evolution · 2022Article
- The Degenerate Tale of Ascidian Tails.Integrative and comparative biology · 2021Review
- Genome-Wide Identification, Comparison, and Expression Analysis of Transcription Factors in AscidianInternational journal of molecular sciences · 2021Article
- Homeotic Genes: Clustering, Modularity, and Diversity.Frontiers in cell and developmental biology · 2021Review
- Review
- Inferring Tunicate Relationships and the Evolution of the Tunicate Hox Cluster with the Genome of Corella inflata.Genome biology and evolution · 2020Article
- The notochord gene regulatory network in chordate evolution: Conservation and divergence from Ciona to vertebrates.Current topics in developmental biology · 2020Review
- Hox gene expression during development of the phoronidEvoDevo · 2020Article
15 more citing papers are in PubMed but not listed here.
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4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ascidians, belonging to the subphylum Urochordata, the earliest branch from the lineage to the vertebrates, exhibit a prototypical morphogenesis of chordates in the larval development, although they subsequently metamorphose into adults with a unique body structure. Recent draft genome analysis of the ascidian Ciona intestinalis has identified 9 Hox genes, which, however, have been located on five scaffolds. Similarly, expression patterns of Ciona Hox genes are largely unknown, although some data have been available for a few Hox member genes. Thus, the cluster structure and colinearity of Hox genes are still an enigma in C. intestinalis. To address these issues, we used fluorescence in situ hybridization and whole-mount in situ hybridization techniques and examined the genomic organization and spatiotemporal expression of all Hox as well as extended Hox member genes (Evx and Mox) of C. intestinalis. We found that seven of nine Ciona Hox genes are located on a single chromosome with some ordering exceptions, and the other genes, including Evx and Mox, are located on three other chromosomes. Some Ciona Hox genes, if not all, exhibited spatially coordinated expression within the larval central nervous system and the gut of the juvenile. In light of these observations, we suggest that the cluster organization and colinearity of the Hox genes are under dispersing and disintegrating conditions in C. intestinalis.
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