ArticleMolecular cell2004
Conserved translational frameshift in dsDNA bacteriophage tail assembly genes.
Article in Molecular cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 151 papers.
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151 citing papers in PubMed.
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- Identification and characterization of integrated prophages and CRISPR-Cas system in Bacillus subtilis RS10 genome.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- PRFect: a tool to predict programmed ribosomal frameshifts in prokaryotic and viral genomes.BMC bioinformatics · 2024Article
- Genome sequences of six cluster CT and two cluster DJ bacteriophages that infectMicrobiology resource announcements · 2023Article
- Complete genome sequences of microbacterium phages Tedro and BAjuniper.Microbiology resource announcements · 2023Article
- The characterization and genome analysis of a novel phage phiA034 targeting multiple species of Aeromonas.Virus research · 2023Article
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- Complete Genome Sequences of Actinobacteriophages Anaysia and Caviar.Microbiology resource announcements · 2022Article
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- Comparative Genomics of Six LyticPHAGE (New Rochelle, N.Y.) · 2022Article
- Suggestion for a new bacteriophage genus for the Klebsiella pneumoniae phage vB_KpnS-Carvaje.Current genetics · 2022Article
- "Pseudo-pseudogenes" in bacterial genomes: Proteogenomics reveals a wide but low protein expression of pseudogenes in Salmonella enterica.Nucleic acids research · 2022Article
- An InducibleViruses · 2022Article
91 more citing papers are in PubMed but not listed here.
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3 authors.
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Abstract
A programmed translational frameshift similar to frameshifts in retroviral gag-pol genes and bacterial insertion elements was found to be strongly conserved in tail assembly genes of dsDNA phages and to be independent of sequence similarities. In bacteriophage lambda, this frameshift controls production of two proteins with overlapping sequences, gpG and gpGT, that are required for tail assembly. We developed bioinformatic approaches to identify analogous -1 frameshifting sites and experimentally confirmed our predictions for five additional phages. Clear evidence was also found for an unusual but analogous -2 frameshift in phage Mu. Frameshifting sites could be identified for most phages with contractile or noncontractile tails whose length is controlled by a tape measure protein. Phages from a broad spectrum of hosts spanning Eubacteria and Archaea appear to conserve this frameshift as a fundamental component of their tail assembly mechanisms, supporting the idea that their tail genes share a common, distant ancestry.
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