ArticleThe Journal of clinical investigation2004
Differential subunit composition of the G protein-activated inward-rectifier potassium channel during cardiac development.
Article in The Journal of clinical investigation, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 43 citations in OpenAlex.
- Gene expression profiling of extraocular muscles in primary inferior oblique overaction.PeerJ · 2025Article
- An In Silico Investigation of the Pathogenic G151R G Protein-Gated Inwardly Rectifying KBiology · 2024Article
- The W101CInternational journal of molecular sciences · 2023Article
- Impaired Human Cardiac Cell Development due to NOTCH1 Deficiency.Circulation research · 2023Article
- Review
- Potassium channels in the sinoatrial node and their role in heart rate control.Channels (Austin, Tex.) · 2018Review
- Murine Short Axis Ventricular Heart Slices for Electrophysiological Studies.Journal of visualized experiments : JoVE · 2017Article
- Article
- Spatiotemporal stability of neonatal rat cardiomyocyte monolayers spontaneous activity is dependent on the culture substrate.PloS one · 2015Article
- Gremlin 2 promotes differentiation of embryonic stem cells to atrial fate by activation of the JNK signaling pathway.Stem cells (Dayton, Ohio) · 2014Article
- Functional expression and modulation of the L-type Ca2+ current in embryonic heart cells.Pediatric cardiology · 2012Article
- Genome-wide association analysis identifies multiple loci related to resting heart rate.Human molecular genetics · 2010Article
- Do caveolae have a role in the fidelity and dynamics of receptor activation of G-protein-gated inwardly rectifying potassium channels?The Journal of biological chemistry · 2010Article
- Generation of a constitutive Na+-dependent inward-rectifier current in rat adult atrial myocytes by overexpression of Kir3.4.The Journal of physiology · 2007Article
- Intracellular Ca2+ oscillations, a potential pacemaking mechanism in early embryonic heart cells.The Journal of general physiology · 2007Article
- Engraftment of engineered ES cell-derived cardiomyocytes but not BM cells restores contractile function to the infarcted myocardium.The Journal of experimental medicine · 2006Article
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parasympathetic slowing of the heart rate is predominantly mediated by acetylcholine-dependent activation of the G protein-gated potassium (K+) channel (IK,ACh). This channel is composed of 2 inward-rectifier K+ (Kir) channel subunits, Kir3.1 and Kir3.4, that display distinct functional properties. Here we show that subunit composition of IK,ACh changes during embryonic development. At early stages, IK,ACh is primarily formed by Kir3.1, while in late embryonic and adult cells, Kir3.4 is the predominant subunit. This change in subunit composition results in reduced rectification of IK,ACh, allowing for marked K+ currents over the whole physiological voltage range. As a consequence, IK,ACh is able to generate the membrane hyperpolarization that underlies the strong negative chronotropy occurring in late- but not early-stage atrial cardiomyocytes upon application of muscarinic agonists. Both strong negative chronotropy and membrane hyperpolarization can be induced in early-stage cardiomyocytes by viral overexpression of the mildly rectifying Kir3.4 subunit. Thus, a switch in subunit composition is used to adopt IK,ACh to its functional role in adult cardiomyocytes.
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