ArticleProceedings of the National Academy of Sciences of the United States of America2004
Dynamical transition and proteinquake in photoactive yellow protein.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- The Wako-Saitô-Muñoz-Eaton Model for Predicting Protein Folding and Dynamics.Molecules (Basel, Switzerland) · 2022Review
- Ultrafast coherent motion and helix rearrangement of homodimeric hemoglobin visualized with femtosecond X-ray solution scattering.Nature communications · 2021Article
- Comparative Study of the Collective Dynamics of Proteins and Inorganic Nanoparticles.Scientific reports · 2017Article
- Cooperativity and modularity in protein folding.Biophysics and physicobiology · 2016Review
- Characterization of protein folding by a Φ-value calculation with a statistical-mechanical model.Biophysics and physicobiology · 2016Article
- Ultrafast myoglobin structural dynamics observed with an X-ray free-electron laser.Nature communications · 2015Article
- Characterizing antiprion compounds based on their binding properties to prion proteins: implications as medical chaperones.Protein science : a publication of the Protein Society · 2013Article
- Entropic mechanism of large fluctuation in allosteric transition.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Cooperativity, connectivity, and folding pathways of multidomain proteins.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Predicting the order in which contacts are broken during single molecule protein stretching experiments.Proteins · 2008Article
- PAS domain allostery and light-induced conformational changes in photoactive yellow protein upon I2 intermediate formation, probed with enhanced hydrogen/deuterium exchange mass spectrometry.Journal of molecular biology · 2006Article
- Coarse-grained normal mode analysis in structural biology.Current opinion in structural biology · 2005Review
- Predicting the signaling state of photoactive yellow protein.Biophysical journal · 2005Article
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2 authors.
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Abstract
Conformational dynamics in protein functioning covers a wide range of time scales from nanosecond fluctuations around a conformation to the large-amplitude conformational changes of milliseconds or longer. We illustrate a picture of cooperative coupling among such motions of different time scales in a model protein, photoactive yellow protein, by proposing a model that can consistently explain the experimental results on the photocycle of photoactive yellow protein. The model provides a scenario in which the global collective motion induced by the unfolding of the N-terminal domain promotes the loosening of the atomistic packing around the chromophore, which produces the favorable molecular environment for the photoexcited chromophore, thereby stabilizing the partially unfolded intermediate in the photocycle. The proteinquake, the large conformational change triggered by the local structural disturbance, plays a decisive role in controlling the kinetics of functioning.
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