ArticleProceedings of the National Academy of Sciences of the United States of America2004
Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers.
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Who cites it
127 citing papers in PubMed, 270 citations in OpenAlex.
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- Gene regulation inMicrobiology and molecular biology reviews : MMBR · 2025Review
- Lessons from the model gut BacteroidalesJournal of bacteriology · 2025Review
- Genomic alterations in Bacteroides fragilis favor adaptation in colorectal cancer microenvironment.BMC genomics · 2025Article
- Carbohydrate Deacetylase Unique to Gut Microbe Bacteroides Reveals Atypical Structure.Biochemistry · 2025Article
- A ubiquitous mobile genetic element changes the antagonistic weaponry of a human gut symbiont.Science (New York, N.Y.) · 2024Article
- Dynamic genetic adaptation of Bacteroides thetaiotaomicron during murine gut colonization.Cell reports · 2023Article
- Single-cell analysis of multiple invertible promoters reveals differential inversion rates as a strong determinant of bacterial population heterogeneity.Science advances · 2023Article
- Mucin glycans and their degradation by gut microbiota.Glycoconjugate journal · 2023Review
- Links between Diet, Intestinal Anaerobes, Microbial Metabolites and Health.Biomedicines · 2023Review
- Systematic identification of gene-altering programmed inversions across the bacterial domain.Nucleic acids research · 2023Article
- Proteomic analysis of metronidazole resistance in the human facultative pathogenFrontiers in microbiology · 2023Article
- Modulatory Effect of Gut Microbiota on the Gut-Brain, Gut-Bone Axes, and the Impact of Cannabinoids.Metabolites · 2022Review
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- From genome structure to function: insights into structural variation in microbiology.Current opinion in microbiology · 2022Review
67 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacteroides are predominant human colonic commensals, but the principal pathogenic species, Bacteroides fragilis (BF), lives closely associated with the mucosal surface, whereas a second major species, Bacteroides thetaiotaomicron (BT), concentrates within the colon. We find corresponding differences in their genomes, based on determination of the genome sequence of BF and comparative analysis with BT. Both species have acquired two mechanisms that contribute to their dominance among the colonic microbiota: an exceptional capability to use a wide range of dietary polysaccharides by gene amplification and the capacity to create variable surface antigenicities by multiple DNA inversion systems. However, the gene amplification for polysaccharide assimilation is more developed in BT, in keeping with its internal localization. In contrast, external antigenic structures can be changed more systematically in BF. Thereby, at the mucosal surface, where microbes encounter continuous attack by host defenses, BF evasion of the immune system is favored, and its colonization and infectious potential are increased.
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