ArticleBritish journal of pharmacology2004
Evidence for P2Y1, P2Y2, P2Y6 and atypical UTP-sensitive receptors coupled to rises in intracellular calcium in mouse cultured superior cervical ganglion neurons and glia.
Article in British journal of pharmacology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Naringin Relieves Diabetic Cardiac Autonomic Neuropathy Mediated by P2YFrontiers in pharmacology · 2022Article
- Electroacupuncture Alleviates Bladder Overactivity via Inhabiting Bladder P2XEvidence-based complementary and alternative medicine : eCAM · 2020Article
- Characterization of ectonucleotidase expression in the rat carotid body: regulation by chronic hypoxia.American journal of physiology. Cell physiology · 2017Article
- Ganglionic GFAPJCI insight · 2017Article
- Targeting sympathetic glia for treating cardiovascular diseases.Receptors & clinical investigation · 2017Article
- P2Y receptors in Alzheimer's disease.Biology of the cell · 2015Review
- Epithelial wounds induce differential phosphorylation changes in response to purinergic and EGF receptor activation.The American journal of pathology · 2013Article
- P2Y receptors in the mammalian nervous system: pharmacology, ligands and therapeutic potential.CNS & neurological disorders drug targets · 2012Review
- P2 receptors for extracellular nucleotides in the central nervous system: role of P2X7 and P2Y₂ receptor interactions in neuroinflammation.Molecular neurobiology · 2012Review
- Pharmacological characterization of uracil nucleotide-preferring P2Y receptors modulating intestinal motility: a study on mouse ileum.Purinergic signalling · 2012Article
- AKAP79/150 signal complexes in G-protein modulation of neuronal ion channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Combined phosphoinositide and Ca2+ signals mediating receptor specificity toward neuronal Ca2+ channels.The Journal of biological chemistry · 2011Article
- The presence of bestrophin-1 modulates the Ca2+ recruitment from Ca2+ stores in the ER.Pflugers Archiv : European journal of physiology · 2010Article
- Selective loss of P2Y2 nucleotide receptor immunoreactivity is associated with Alzheimer's disease neuropathology.Journal of neural transmission (Vienna, Austria : 1996) · 2008Article
- ATP induces guinea pig gallbladder smooth muscle excitability via the P2Y4 receptor and COX-1 activity.American journal of physiology. Gastrointestinal and liver physiology · 2008Article
- Contribution of P2Y(1) receptors to ADP signalling in mouse spinal cord cultures.Neuroscience letters · 2008Article
- Intestinal ischemia-reperfusion injury alters purinergic receptor expression in clinically relevant extraintestinal organs.The Journal of surgical research · 2008Article
- P2 receptor-mediated modulation of neurotransmitter release-an update.Purinergic signalling · 2007Article
- Inositol triphosphate-mediated Ca2+ signals direct purinergic P2Y receptor regulation of neuronal ion channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Activation of P2Y1 nucleotide receptors induces inhibition of the M-type K+ current in rat hippocampal pyramidal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
1 P2Y receptors are expressed in the nervous system and are involved in calcium signalling in neurons and glia. In the superior cervical ganglion (SCG), RT-PCR analysis indicated the presence of P2Y(1,2&6) receptors. Rises in intracellular calcium in response to P2Y receptor stimulation were determined from adult mouse cultured SCG neurons and glia. 2 ADP evoked suramin (100 microM)- and pyridoxalphosphate-6-azophenyl-2',4'-disulphonic acid (PPADS, 30 microM)-sensitive rises in intracellular calcium in approximately 80% of SCG neurons (EC50 approximately 20 microM). ADP-evoked responses were abolished in neurons from P2Y1 receptor-deficient mice (responses to UTP were unaffected). 3 The pyrimidines UTP (EC50 approximately 85 microM) and UDP (EC50>90 microM) evoked PPADS- and suramin-sensitive responses in approximately 70 and approximately 20% of SCG neurons, respectively. 4 In SCG glial cells, ADP (EC50 approximately 30 microM) evoked calcium responses in approximately 50% of glia. These were suramin and PPADS sensitive and essentially abolished in SCG glial cells cultured from adult P2Y1 receptor-deficient mice. 5 UTP (EC50 approximately 25 microM) and UDP (EC50>200 microM) evoked suramin- and pyridoxalphosphate-6-azophenyl-2',5'-disulphonate-sensitive rises in calcium in approximately 60 and 20% SCG glial cells, respectively. 6 These results indicate the presence of several P2Y receptors coupled to an increase in intracellular calcium in the SCG: ADP-sensitive P2Y1 receptors and UDP-sensitive P2Y6 receptors in SCG neurons and glial cells, a novel UTP-sensitive P2Y receptor in SCG neurons and UTP- and ATP-sensitive P2Y2 receptors in SCG glia.
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