Evidence map›Paper›PMID 15466421›Full record

ArticleGenetics2005

A screen for Schizosaccharomyces pombe mutants defective in rereplication identifies new alleles of rad4+, cut9+ and psf2+.

Eliana B Gómez, Vanessa T Angeles, Susan L Forsburg

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
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  7. Crystal structure of the GINS complex and functional insights into its role in DNA replication.Proceedings of the National Academy of Sciences of the United States of America · 2007
    Article
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  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Eliana B GómezMolecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA.
Vanessa T Angeles
Susan L Forsburg
University of Southern California · USSalk Institute for Biological Studies · US

Funding

Genetic Analysis of MSM Protein Function in S. PombeR01GM059321 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FORSBURG, SUSAN L · 1999 to 2012
$4.7M
NIGMS NIH HHS GM-059321NIGMS NIH HHS R01 GM059321
6 · The paper itself

Abstract

Fission yeast mutants defective in DNA replication have widely varying morphological phenotypes. We designed a screen for temperature-sensitive mutants defective in the process of replication regardless of morphology by isolating strains unable to rereplicate their DNA in the absence of cyclin B (Cdc13). Of the 42 rereplication-defective mutants analyzed, we were able to clone complementing plasmids for 10. This screen identified new alleles of the APC subunit cut9(+), the initiation/checkpoint factor rad4(+)/cut5(+), and the first mutant allele of psf2(+), a subunit of the novel GINS replication complex. Other genes identified are likely to play general roles in gene expression and protein localization.

Indexed as

Cell CycleDNA ReplicationMutationSchizosaccharomyces pombe ProteinsAllelesApc6 Subunit, Anaphase-Promoting Complex-CyclosomeCyclin BDNA-Binding ProteinsDNA, FungalGenetic Complementation TestNuclear ProteinsPlasmidsSchizosaccharomycesTemperatureTransglutaminasesApc6 Subunit, Anaphase-Promoting Complex-CyclosomeCUT9 protein, S pombeCyclin BDNA-Binding ProteinsDNA, FungalNuclear ProteinsRAD4 protein, S pombeSchizosaccharomyces pombe ProteinsTransglutaminases

Identifiers

PMID15466421
PMCPMC1448876
OpenAlexW2035482537

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.