ArticleThe American journal of pathology2004
Activated hepatic stellate cells express keratinocyte growth factor in chronic liver disease.
Article in The American journal of pathology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 77 citations in OpenAlex.
- Inhibition of FGFR2 Signaling by Cynaroside Attenuates Liver Fibrosis.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Understanding the cellular interactome of non-alcoholic fatty liver disease.JHEP reports : innovation in hepatology · 2022Review
- Fetal androgen exposure is a determinant of adult male metabolic health.Scientific reports · 2019Article
- Insulin resistance disrupts epithelial repair and niche-progenitor Fgf signaling during chronic liver injury.PLoS biology · 2019Article
- Hepatic progenitor cell activation in liver repair.Liver research (Beijing, China) · 2017Article
- Intestinal fungi contribute to development of alcoholic liver disease.The Journal of clinical investigation · 2017Article
- Regulation of Hepatic Stellate Cells and Fibrogenesis by Fibroblast Growth Factors.BioMed research international · 2016Review
- Advances in hepatic stem/progenitor cell biology.EXCLI journal · 2015Review
- Cancer-associated fibroblasts in digestive tumors.World journal of gastroenterology · 2014Review
- Fibroblast growth factor (Fgf) signaling pathway regulates liver homeostasis in zebrafish.Transgenic research · 2013Article
- FGF7 is a functional niche signal required for stimulation of adult liver progenitor cells that support liver regeneration.Genes & development · 2013Article
- Peroxisome proliferator-activated receptor-γ as a therapeutic target for hepatic fibrosis: from bench to bedside.Cellular and molecular life sciences : CMLS · 2013Review
- Adiponectin upregulates hepatocyte CMKLR1 which is reduced in human fatty liver.Molecular and cellular endocrinology · 2012Article
- Therapeutic effects of vitamin A on experimental cholestatic rats with hepatic fibrosis.Pediatric surgery international · 2011Article
- Epigenetic cell fate regulation of hepatic stellate cells.Hepatology research : the official journal of the Japan Society of Hepatology · 2011Article
- Mechanisms of hepatic fibrogenesis.Best practice & research. Clinical gastroenterology · 2011Review
- FGF receptors 1 and 2 control chemically induced injury and compound detoxification in regenerating livers of mice.Gastroenterology · 2010Article
- Reduced expression of fibroblast growth factor receptor 2IIIb in hepatocellular carcinoma induces a more aggressive growth.The American journal of pathology · 2010Article
- Activated hepatic stellate cells promote tumorigenicity of hepatocellular carcinoma.Cancer science · 2009Article
- Advances in antifibrotic therapy.Expert review of gastroenterology & hepatology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Keratinocyte growth factor (KGF), a member of the fibroblast growth factor (FGF) family, is a specific mitogen for different types of epithelial cells and a potent survival factor for these cells under stress conditions. KGF expression increases strongly after injury to various tissues, including the skin and the intestine, and signaling via the KGF receptor was shown to be crucial for repair of skin wounds and for liver regeneration. Here we demonstrate an increased expression of KGF in chronic liver disease associated with fibrosis. The extent of KGF overexpression correlated strongly with the stage of fibrosis. As the cellular source of KGF we identified activated hepatic stellate cells (HSCs)/myofibroblasts. In contrast to the ligand, the KGF receptor, FGFR2-IIIb, was exclusively expressed by hepatocytes, but not by activated HSCs or other parenchymal or nonparenchymal liver cells. Based on the known effects of KGF on hepatocytes in vitro, our findings suggest that HSC/myofibroblast-derived KGF may enhance liver regeneration and/or hepatocyte survival in patients with chronic liver disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.