ArticleThe American journal of pathology2004
Impaired lung dendritic cell activation in CCR2 knockout mice.
Article in The American journal of pathology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 50 citations in OpenAlex.
- CCR6 is essential for effective immunity againstInfection and immunity · 2026Article
- Unraveling the pleiotropic effects of CCR2-dependent signal transduction in fibrosis development.Theranostics · 2026Review
- Gene function revealed at the moment of stochastic gene silencingCommunications biology · 2025Article
- Immunometabolic cues recompose and reprogram the microenvironment around implanted biomaterials.Nature biomedical engineering · 2024Article
- Nutritional immunomodulation of Atlantic salmon response toFrontiers in molecular biosciences · 2022Article
- FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity.Nature communications · 2021Article
- CCR2 mediates Helicobacter pylori-induced immune tolerance and contributes to mucosal homeostasis.Helicobacter · 2017Article
- In vivo mechanisms involved in enhanced protection utilizing an Fc receptor-targeted mucosal vaccine platform in a bacterial vaccine and challenge model.Infection and immunity · 2015Article
- Article
- The multiple faces of CCL13 in immunity and inflammation.Inflammopharmacology · 2013Review
- Heterogeneity of lung mononuclear phagocytes during pneumonia: contribution of chemokine receptors.American journal of physiology. Lung cellular and molecular physiology · 2013Article
- Chemokines in innate and adaptive granuloma formation.Frontiers in immunology · 2013Article
- Article
- Early induction of CCL7 downstream of TLR9 signaling promotes the development of robust immunity to cryptococcal infection.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- CCR6 as a mediator of immunity in the lung and gut.Experimental cell research · 2011Review
- CC chemokine receptor 4 contributes to innate NK and chronic stage T helper cell recall responses during Mycobacterium bovis infection.The American journal of pathology · 2011Article
- Cysteine-cysteinyl chemokine receptor 6 mediates invariant natural killer T cell airway recruitment and innate stage resistance during mycobacterial infection.Journal of innate immunity · 2011Article
- CCR2 regulates monocyte recruitment as well as CD4 T1 allorecognition after lung transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2010Article
- Lung vascular endothelial growth factor expression induces local myeloid dendritic cell activation.Clinical immunology (Orlando, Fla.) · 2009Article
- The role of chemokines in virus-associated asthma exacerbations.Current allergy and asthma reports · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
Dendritic cell (DC) recruitment is a hallmark event in antigen (Ag)-challenged lungs. We previously reported models for analyzing DC migration and activation in the lung after Th1- or Th2-eliciting pathogen Ag-bead challenge. To determine the role of chemokines in DC mobilization, we applied this analysis to CCR1, CCR2, CCR5, and CCR6 chemokine receptor knockout mice. Both Mycobacteria bovis protein Ags and helminthic, Schistosoma mansoni egg Ags elicited multiple chemokines, including CCR1, CCR2, CCR5, and to a lesser extent CCR6 ligands. DCs from wild-type lungs expressed transcripts for chemokine receptors, CCR1, CCR2, CCR5, and CXCR4. In all knockout strains, CD11c+ cells were recruited to Ag-beads likely because of receptor redundancy. However, DCs in CCR2-/- mice had significantly decreased MHCII and CD40 expression. This was associated with abrogated cytokine production in draining lymph node cultures. Analysis of local innate inflammation revealed a 50% reduction in macrophage recruitment in CCR2-/- mice. Bone marrow chimeras of mixed CCR2+/+ green fluorescent protein transgenic and CCR2-/- green fluorescent protein-negative cells confirmed the DC maturation defect was only among the latter population. In conclusion, CCR2 knockout confers an intrinsic DC activation defect and CCR2 ligands likely promote the local activation/maturation of inflammatory DCs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.