ArticleThe American journal of pathology2004
Deficient eosinophil chemotaxis-promoting activity of genetically normal mast cells transplanted into subcutaneous tissue of Mitfmi-vga9/Mitfmi-vga9 mice: comparison of the activity and mast cell distribution pattern with KitW/KitW-vMice.
Article in The American journal of pathology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 6 citations in OpenAlex.
- Transcriptional Regulation of Mouse Mast Cell Differentiation and the Role of Human Lung Mast Cells in Airway Inflammation.Immunological reviews · 2025Review
- Transcriptional regulation of mast cell and basophil lineage commitment.Seminars in immunopathology · 2016Review
- Tachykinins and their receptors: contributions to physiological control and the mechanisms of disease.Physiological reviews · 2014Review
- The naive airway hyperresponsiveness of the A/J mouse is Kit-mediated.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Development of mast cells.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2007Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the practical lack of mast cells in the skin tissue of WBB6F(1)-Kit(W)/Kit(W-v), the skin tissue of WBB6F(1)-Mitf(mi-vga9)/Mitf(mi-vga9) mice contains one third of mast cells than that of WBB6F(1)-+/+ mice. We attempted to investigate the function of the decreased but appreciable number of mast cells in the skin of WBB6F(1)-Mitf(mi-vga9)/Mitf(mi-vga9) mice. The substance P (SP)-induced eosinophil infiltration was examined using air-bleb assay. The air-bleb membrane was composed of the subcutaneous connective tissue. Unexpectedly, we found that the air-bleb membranes formed in the back of WBB6F(1)-Mitf(mi-vga9)/Mitf(mi-vga9) mice contained no mast cells. The WBB6F(1)-Mitf(mi-vga9)/Mitf(mi-vga9) mice showed impaired SP-induced eosinophil infiltration as observed in WBB6F(1)-Kit(W)/Kit(W-v) mice, indicating that mast cells detected in the dermis of WBB6F(1)-Mitf(mi-vga9)/Mitf(mi-vga9) mice did not help SP-induced eosinophil infiltration. Subcutaneous transplantation of cultured mast cells from WBB6F(1)-+/+ mice normalized SP-induced eosinophil infiltration in WBB6F(1)-Kit(W)/Kit(W-v) mice but not in WBB6F(1)-Mitf(mi-vga9)/Mitf(mi-vga9) mice. The greater number and the more dispersed distribution pattern of mast cells that appeared in the subcutaneous connective tissue of WBB6F(1)-Kit(W)/Kit(W-v) mice after the transplantation appeared to explain the difference between WBB6F(1)-Kit(W)/Kit(W-v) and WBB6F(1)-Mitf(mi-vga9)/Mitf(mi-vga9) mice.
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