ArticleGenome research2004
Mitochondrial genome variation in eastern Asia and the peopling of Japan.
Article in Genome research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 195 papers, 1 of them a synthesis that pooled it.
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Who cites it
195 citing papers in PubMed, 1 synthesis or guideline pooled it.
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- Population expansion from central plain to northern coastal China inferred from ancient human genomes.iScience · 2024Article
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- High prevalence of m.1555A > G in patients with hearing loss in the Baikal Lake region of Russia as a result of founder effect.Scientific reports · 2024Article
- Bronze age Northern Eurasian genetics in the context of development of metallurgy and Siberian ancestry.Communications biology · 2024Article
- TPMA: A two pointers meta-alignment tool to ensemble different multiple nucleic acid sequence alignments.PLoS computational biology · 2024Article
- Does the human leukocyte antigen's relatively homogeneous genetic background relate to better lung transplantation outcomes in Japan?Journal of thoracic disease · 2023Review
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- High Mitochondrial Haplotype Diversity Found in Three Pre-Hispanic Groups from Colombia.Genes · 2023Article
- The first maternal genetic study of hunter-gatherers from Vietnam.Molecular genetics and genomics : MGG · 2023Article
- Mitochondria dysfunction and bipolar disorder: From pathology to therapy.IBRO neuroscience reports · 2023Article
- Major depressive disorder is correlated with the mitochondrialWorld journal of psychiatry · 2023Article
- Diversity and distribution of mitochondrial DNA in non-Austronesian-speaking Taiwanese individuals.Human genome variation · 2023Article
- A multidisciplinary study on the social customs of the Tang Empire in the Medieval Ages.PloS one · 2023Article
- A novel ND1 mitochondrial DNA mutation is maternally inherited in growth hormone transgenesis in amago salmon (Oncorhynchus masou ishikawae).Scientific reports · 2022Article
- The frequency of the known mitochondrial variants associated with drug-induced toxicity in a Korean population.BMC medical genomics · 2022Article
135 more citing papers are in PubMed but not listed here.
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Authors and funding
28 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To construct an East Asia mitochondrial DNA (mtDNA) phylogeny, we sequenced the complete mitochondrial genomes of 672 Japanese individuals (http://www.giib.or.jp/mtsnp/index_e.html). This allowed us to perform a phylogenetic analysis with a pool of 942 Asiatic sequences. New clades and subclades emerged from the Japanese data. On the basis of this unequivocal phylogeny, we classified 4713 Asian partial mitochondrial sequences, with <10% ambiguity. Applying population and phylogeographic methods, we used these sequences to shed light on the controversial issue of the peopling of Japan. Population-based comparisons confirmed that present-day Japanese have their closest genetic affinity to northern Asian populations, especially to Koreans, which finding is congruent with the proposed Continental gene flow to Japan after the Yayoi period. This phylogeographic approach unraveled a high degree of differentiation in Paleolithic Japanese. Ancient southern and northern migrations were detected based on the existence of basic M and N lineages in Ryukyuans and Ainu. Direct connections with Tibet, parallel to those found for the Y-chromosome, were also apparent. Furthermore, the highest diversity found in Japan for some derived clades suggests that Japan could be included in an area of migratory expansion to Continental Asia. All the theories that have been proposed up to now to explain the peopling of Japan seem insufficient to accommodate fully this complex picture.
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