ArticlePlant physiology2004
Evidence for serine/threonine and histidine kinase activity in the tobacco ethylene receptor protein NTHK2.
Article in Plant physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Integrated morpho-physiological, metabolomic and transcriptomic profiling uncovers ethylene-mediated metabolic regulation shaping drought resilience in wheat.BMC plant biology · 2026Article
- Non-Canonical Inter-Protein Interactions of Key Proteins Belonging to Cytokinin Signaling Pathways.Plants (Basel, Switzerland) · 2025Review
- Ethylene Signaling in Regulating Plant Growth, Development, and Stress Responses.Plants (Basel, Switzerland) · 2025Review
- Characterization of CHARK, an unusual cytokinin receptor of rice.Scientific reports · 2021Article
- Melatonin Enhances Seed Germination and Seedling Growth ofFrontiers in plant science · 2021Article
- ETR1 Integrates Response to Ethylene and Cytokinins into a Single Multistep Phosphorelay Pathway to Control Root Growth.Molecular plant · 2019Article
- Evidence of the functional role of the ethylene receptor genes SlETR4 and SlETR5 in ethylene signal transduction in tomato.Molecular genetics and genomics : MGG · 2019Article
- Tobacco Translationally Controlled Tumor Protein Interacts with Ethylene Receptor Tobacco Histidine Kinase1 and Enhances Plant Growth through Promotion of Cell Proliferation.Plant physiology · 2015Article
- Three SAUR proteins SAUR76, SAUR77 and SAUR78 promote plant growth in Arabidopsis.Scientific reports · 2015Article
- Histidine kinases in plants: cross talk between hormone and stress responses.Plant signaling & behavior · 2012Review
- Ligand-induced alterations in the phosphorylation state of ethylene receptors in tomato fruit.Plant physiology · 2012Article
- Genome-wide analysis of two-component systems and prediction of stress-responsive two-component system members in soybean.DNA research : an international journal for rapid publication of reports on genes and genomes · 2010Article
- Convergence of Ser/Thr and two-component signaling to coordinate expression of the dormancy regulon in Mycobacterium tuberculosis.The Journal of biological chemistry · 2010Article
- The ethylene receptor ETR2 delays floral transition and affects starch accumulation in rice.The Plant cell · 2009Article
- Threonine phosphorylation prevents promoter DNA binding of the Group B Streptococcus response regulator CovR.Molecular microbiology · 2009Article
- The ancestral symbiont sensor kinase CSK links photosynthesis with gene expression in chloroplasts.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Modulation of ethylene responses affects plant salt-stress responses.Plant physiology · 2007Article
- How ethylene works in the reproductive organs of higher plants: a signaling update from the third millennium.Plant signaling & behavior · 2006Article
- REVERSION-TO-ETHYLENE SENSITIVITY1, a conserved gene that regulates ethylene receptor function in Arabidopsis.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Ethylene signal transduction.Annals of botany · 2005Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ethylene plays important roles in plant growth, development, and stress responses. Two ethylene receptors, ETR1 from Arabidopsis and NTHK1 from tobacco (Nicotiana tabacum), have been found to have His kinase (HK) activity and Ser/Thr kinase activity, respectively, although both show similarity to bacterial two-component HK. Here, we report the characterization of another ethylene receptor homolog gene, NTHK2, from tobacco. This gene also encodes a HK-like protein and is induced by dehydration and CaCl(2) but not significantly affected by NaCl and abscisic acid treatments. The biochemical properties of the yeast (Schizosaccharomyces pombe)-expressed NTHK2 domains were further characterized. We found that NTHK2 possessed Ser/Thr kinase activity in the presence of Mn(2+) and had HK activity in the presence of Ca(2+). Several lines of evidence supported this conclusion, including hydrolytic stability, phosphoamino acid analysis, mutation, deletion, and substrate analysis. These properties have implications in elucidation of the complexity of the ethylene signal transduction pathway and understanding of ethylene functions in plants.
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