ArticlePlant physiology2004
Expression profiling in Medicago truncatula identifies more than 750 genes differentially expressed during nodulation, including many potential regulators of the symbiotic program.
Article in Plant physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers.
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Who cites it
106 citing papers in PubMed, 267 citations in OpenAlex.
- Loss of Nod25 function does not affect nitrogen-fixing symbiosis in Medicago truncatula.Plant molecular biology · 2026Article
- Hormone-modulated transcription factors orchestrating the root nodule symbiosis.Frontiers in plant science · 2026Review
- Plant microbiota feedbacks through dose-responsive expression of general non-self response genes.Nature plants · 2025Article
- Genome and Transcriptome Analysis of theGenes · 2024Article
- Genomic and Metabolic Characterization of Plant Growth-Promoting Rhizobacteria Isolated from Nodules of Clovers Grown in Non-Farmed Soil.International journal of molecular sciences · 2023Article
- It's Not You, It's Me: Medicago truncatula efd-1 Mutant Phenotype Depends on Rhizobium Symbiont.Plant & cell physiology · 2023Article
- Article
- Genes Associated with Biological Nitrogen Fixation Efficiency Identified Using RNA Sequencing in Red Clover (Life (Basel, Switzerland) · 2022Article
- Proteomic Analysis of Alfalfa (Genes · 2022Article
- Time Series Transcriptome Analysis inFrontiers in plant science · 2022Article
- Environmental Cues Contribute to Dynamic Plasma Membrane Organization of Nanodomains Containing Flotillin-1 and Hypersensitive Induced Reaction-1 Proteins inFrontiers in plant science · 2022Article
- The Rhizobium-Legume Symbiosis: Co-opting Successful Stress Management.Frontiers in plant science · 2021Review
- Fulvic acid increases forage legume growth inducing preferential up-regulation of nodulation and signalling-related genes.Journal of experimental botany · 2020Article
- Responses of mature symbiotic nodules to the whole-plant systemic nitrogen signaling.Journal of experimental botany · 2020Article
- Reprogramming of Root Cells during Nitrogen-Fixing Symbiosis Involves Dynamic Polysome Association of Coding and Noncoding RNAs.The Plant cell · 2020Article
- Gene Expression in Nitrogen-Fixing Symbiotic Nodule Cells inThe Plant cell · 2020Review
- Identification of miRNAs linked to peanut nodule functional processes.Journal of biosciences · 2020Article
- Organization and dynamics of functional plant membrane microdomains.Cellular and molecular life sciences : CMLS · 2020Review
- The Ectomycorrhizal FungusThe Plant cell · 2019Article
- Transcriptome analysis of soybean (Glycine max) root genes differentially expressed in rhizobial, arbuscular mycorrhizal, and dual symbiosis.Journal of plant research · 2019Article
46 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we describe a large-scale expression-profiling approach to identify genes differentially regulated during the symbiotic interaction between the model legume Medicago truncatula and the nitrogen-fixing bacterium Sinorhizobium meliloti. Macro- and microarrays containing about 6,000 probes were generated on the basis of three cDNA libraries dedicated to the study of root symbiotic interactions. The experiments performed on wild-type and symbiotic mutant material led us to identify a set of 756 genes either up- or down-regulated at different stages of the nodulation process. Among these, 41 known nodulation marker genes were up-regulated as expected, suggesting that we have identified hundreds of new nodulation marker genes. We discuss the possible involvement of this wide range of genes in various aspects of the symbiotic interaction, such as bacterial infection, nodule formation and functioning, and defense responses. Importantly, we found at least 13 genes that are good candidates to play a role in the regulation of the symbiotic program. This represents substantial progress toward a better understanding of this complex developmental program.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.