ArticleJournal of bacteriology2004
Phosphorylation and RsbX-dependent dephosphorylation of RsbR in the RsbR-RsbS complex of Bacillus subtilis.
Article in Journal of bacteriology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Mixed positive and negative feedback loops drive diverse single-cell gene expression dynamics.Nature communications · 2026Article
- ComK-induced cell death is reversed by upregulating the SigB or Spx pathway inMicrobiology spectrum · 2025Article
- Stressosome-independent but RsbT-dependent environmental stress sensing in Bacillus subtilis.Nature communications · 2025Article
- Giving a signal: how protein phosphorylation helps Bacillus navigate through different life stages.FEMS microbiology reviews · 2023Review
- Prediction and validation of novel SigB regulon members in Bacillus subtilis and regulon structure comparison to Bacillales members.BMC microbiology · 2023Article
- Molecular insights into intra-complex signal transmission during stressosome activation.Communications biology · 2022Article
- The Vibrio vulnificus stressosome is an oxygen-sensor involved in regulating iron metabolism.Communications biology · 2022Article
- Acid stress signals are integrated into the σB-dependent general stress response pathway via the stressosome in the food-borne pathogen Listeria monocytogenes.PLoS pathogens · 2022Article
- Listeria monocytogenes Requires the RsbX Protein To Prevent SigB Activation under Nonstressed Conditions.Journal of bacteriology · 2022Article
- Activation of the Listeria monocytogenes Stressosome in the Intracellular Eukaryotic Environment.Applied and environmental microbiology · 2021Article
- Impact of osmotic stress on the phosphorylation and subcellular location of Listeria monocytogenes stressosome proteins.Scientific reports · 2020Article
- The Stress-Responsive Alternative Sigma Factor SigB ofFrontiers in microbiology · 2020Review
- The σFrontiers in microbiology · 2020Review
- Structural insights into stressosome assembly.IUCrJ · 2019Article
- The cryo-electron microscopy supramolecular structure of the bacterial stressosome unveils its mechanism of activation.Nature communications · 2019Article
- Use of a microfluidic platform to uncover basic features of energy and environmental stress responses in individual cells of Bacillus subtilis.PLoS genetics · 2017Article
- Mechanism and Role of Globin-Coupled Sensor Signalling.Advances in microbial physiology · 2017Review
- An O2-sensing stressosome from a Gram-negative bacterium.Nature communications · 2016Article
- To Modulate Survival under Secondary Stress Conditions, Listeria monocytogenes 10403S Employs RsbX To Downregulate σB Activity in the Poststress Recovery Stage or Stationary Phase.Applied and environmental microbiology · 2016Article
- Genetic evidence for a phosphorylation-independent signal transduction mechanism within the Bacillus subtilis stressosome.PloS one · 2014Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the pathway that controls sigmaB activity, the RsbR-RsbS complex plays an important role by trapping RsbT, a positive regulator of sigmaB of Bacillus subtilis. We have proposed that at the onset of stress, RsbR becomes phosphorylated, resulting in an enhanced activity of RsbT towards RsbS. RsbT is then free to interact with and activate RsbU, which in turn ultimately activates sigmaB. In this study with purified proteins, we used mutant RsbR proteins to analyze the role of its phosphorylatable threonine residues. The results show that the phosphorylation of either of the two RsbT-phosphorylatable threonine residues (T171 and T205) in RsbR enhanced the kinase activity of RsbT towards RsbS. However, it appeared that RsbT preferentially phosphorylates T171. We also present in vitro evidence that identifies RsbX as a potential phosphatase for RsbR T205.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.