ArticleJournal of bacteriology2004
Effect of bile on the cell surface permeability barrier and efflux system of Vibrio cholerae.
Article in Journal of bacteriology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed.
- The Effect of glycocholic acid on the growth, membrane permeability, conjugation and antibiotic susceptibility of Enterobacteriaceae.Frontiers in cellular and infection microbiology · 2025Article
- Intestinal colonization againstAIMS microbiology · 2023Review
- The Role of the Gallbladder, the Intestinal Barrier and the Gut Microbiota in the Development of Food Allergies and Other Disorders.International journal of molecular sciences · 2022Review
- Deletion of Yersinia pestisJournal of bacteriology · 2021Article
- Crosstalks Between Gut Microbiota andFrontiers in cellular and infection microbiology · 2020Review
- The mechanisms that regulate Vibrio parahaemolyticus virulence gene expression differ between pathotypes.Microbial genomics · 2018Article
- Analysis of Shigella flexneri Resistance, Biofilm Formation, and Transcriptional Profile in Response to Bile Salts.Infection and immunity · 2017Article
- Effects of chromosomal deletion of the operon encoding the multiple resistance and pH-related antiporter in Vibrio cholerae.Microbiology (Reading, England) · 2016Article
- Survival of the Fittest: How Bacterial Pathogens Utilize Bile To Enhance Infection.Clinical microbiology reviews · 2016Review
- Identification of a Vibrio cholerae chemoreceptor that senses taurine and amino acids as attractants.Scientific reports · 2016Article
- Vibrio cholerae leuO Transcription Is Positively Regulated by ToxR and Contributes to Bile Resistance.Journal of bacteriology · 2015Article
- Mechanism for inhibition of Vibrio cholerae ToxT activity by the unsaturated fatty acid components of bile.Journal of bacteriology · 2015Article
- The Vibrio cholerae Cpx envelope stress response senses and mediates adaptation to low iron.Journal of bacteriology · 2015Article
- Article
- Fine tuning of virulence regulatory pathways in enteric bacteria in response to varying bile and oxygen concentrations in the gastrointestinal tract.Gut pathogens · 2014Review
- Characterization of BreR interaction with the bile response promoters breAB and breR in Vibrio cholerae.Journal of bacteriology · 2013Article
- Discovering novel bile protection systems in Bifidobacterium breve UCC2003 through functional genomics.Applied and environmental microbiology · 2012Article
- Yersinia pestis AcrAB-TolC in antibiotic resistance and virulence.Antimicrobial agents and chemotherapy · 2012Article
- Article
- Remodelling of the Vibrio cholerae membrane by incorporation of exogenous fatty acids from host and aquatic environments.Molecular microbiology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gram-negative bacteria are inherently impermeable to hydrophobic compounds, due to the synergistic activity of the permeability barrier imposed by the outer membrane and energy dependent efflux systems. The gram-negative, enteric pathogen Vibrio cholerae appears to be deficient in both these activities; the outer membrane is not an effective barrier to hydrophobic permeants, presumably due to the presence of exposed phospholipids on the outer leaflet of the outer membrane, and efflux systems are at best only partially active. When V. cholerae was grown in the presence of bile, entry of hydrophobic compounds into the cells was significantly reduced. No difference was detected in the extent of exposed phospholipids on the outer leaflet of the outer membrane between cells grown in the presence or absence of bile. However, in the presence of energy uncouplers, uptake of hydrophobic probes was comparable between cells grown in the presence or absence of bile, indicating that energy-dependent efflux processes may be involved in restricting the entry of hydrophobic permeants into bile grown cells. Indeed, an efflux system(s) is essential for survival of V. cholerae in the presence of bile. Expression of acrAB, encoding an RND family efflux pump, was significantly increased in V. cholerae cells grown in vitro in the presence of bile and also in cells grown in rabbit intestine.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.