ArticleJournal of bacteriology2004
The glutathione-glutaredoxin system in Rhodobacter capsulatus: part of a complex regulatory network controlling defense against oxidative stress.
Article in Journal of bacteriology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
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- Glutaredoxins are essential for stress adaptation in the cyanobacterium Synechocystis sp. PCC 6803.Frontiers in plant science · 2013Article
- ROS-Mediated Signalling in Bacteria: Zinc-Containing Cys-X-X-Cys Redox Centres and Iron-Based Oxidative Stress.Journal of signal transduction · 2012Article
- A glutathione redox effect on photosynthetic membrane expression in Rhodospirillum rubrum.Journal of bacteriology · 2011Article
- Glutathione and transition-metal homeostasis in Escherichia coli.Journal of bacteriology · 2008Article
- Cellular defenses against superoxide and hydrogen peroxide.Annual review of biochemistry · 2008Review
- Cysteine metabolism-related genes and bacterial resistance to potassium tellurite.Journal of bacteriology · 2007Article
- Genome sequence of Fusobacterium nucleatum subspecies polymorphum - a genetically tractable fusobacterium.PloS one · 2007Article
- Regulation of hydrogen peroxide-dependent gene expression in Rhodobacter sphaeroides: regulatory functions of OxyR.Journal of bacteriology · 2007Article
- Expression of the trxC gene of Rhodobacter capsulatus: response to cellular redox status is mediated by the transcriptional regulator OxyR.Journal of bacteriology · 2006Article
- Thioredoxins in bacteria: functions in oxidative stress response and regulation of thioredoxin genes.Die Naturwissenschaften · 2006Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mutants with defects in components of the glutathione-glutaredoxin (GSH/Grx) system of Rhodobacter capsulatus were constructed to study its role in defense against oxidative stress and the redox-dependent formation of photosynthetic complexes. The lack of the glutaredoxin 3 gene (grxC) or the glutathione synthetase B gene (gshB) resulted in lower growth rates under aerobic conditions and higher sensitivity to oxidative stress, confirming the role of the GSH/Grx system in oxidative stress defense. Both mutants are highly sensitive to disulfide stress, indicating a major contribution of the GSH/Grx system to the thiol-disulfide redox buffer in the cytoplasm. Like mutations in the thioredoxin system, mutations in the GSH/Grx system affected the formation of photosynthetic complexes, which is redox dependent in R. capsulatus. Expression of the genes grxC, gshB, grxA for glutaredoxin 1, and gorA for glutathione reductase, all encoding components of the GSH/Grx system, was not induced by oxidative stress. Other genes, for which a role in oxidative stress was established in Escherichia coli, acnA, fpr, fur, and katG, were strongly induced by oxidative stress in R. capsulatus. Mutations in the grxC, and/or gshB, and/or trxC (thioredoxin 2) genes affected expression of these genes, indicating an interplay of the different defense systems against oxidative stress. The OxyR and the SoxRS regulons control the expression of many genes involved in oxidative stress defense in E. coli in response to H2O2 and superoxide, respectively. Our data and the available genome sequence of R. capsulatus suggest that a SoxRS system is lacking but an alternative superoxide specific regulator exists in R. capsulatus. While the expression of gorA and grxA is regulated by H2O2 in E. coli this is not the case in R. capsulatus, indicating that the OxyR regulons of these two species are significantly different.
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