ArticleJournal of medical genetics2004
A genome-wide linkage scan for bone mineral density in an extended sample: evidence for linkage on 11q23 and Xq27.
Article in Journal of medical genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Meta-analysis of genome-wide scans provides evidence for sex- and site-specific regulation of bone mass.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2007Pooled it
- Meta-analysis of genome-wide linkage studies for bone mineral density.Journal of human genetics · 2006Pooled it
- A single genetic locus associated with pediatric fractures: A genome-wide association study on 3,230 patients.Experimental and therapeutic medicine · 2020Article
- Article
- Advanced Genetic Approaches in Discovery and Characterization of Genes Involved With Osteoporosis in Mouse and Human.Frontiers in genetics · 2019Review
- Loss of Mpzl3 function causes various skin abnormalities and greatly reduced adipose depots.The Journal of investigative dermatology · 2014Article
- SNP rs6265 regulates protein phosphorylation and osteoblast differentiation and influences BMD in humans.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2013Article
- Sex and the single nucleotide polymorphism: exploring the genetic causes of skeletal sex differences.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2012Article
- Article
- Bone mineral density is linked to 1p36 and 7p15-13 in a southern Chinese population.Journal of bone and mineral metabolism · 2011Article
- Genetic and hormonal control of bone volume, architecture, and remodeling in XXY mice.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2010Article
- Genes influencing spinal bone mineral density in inbred F344, LEW, COP, and DA rats.Functional & integrative genomics · 2010Article
- Association analyses of vitamin D-binding protein gene with compression strength index variation in Caucasian nuclear families.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2010Article
- Quantitative trait locus on chromosome 1q influences bone loss in young Mexican American adults.Calcified tissue international · 2009Article
- Choice of study phenotype in osteoporosis genetic research.Journal of bone and mineral metabolism · 2009Review
- A bivariate whole genome linkage study identified genomic regions influencing both BMD and bone structure.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2008Article
- Vitamin D-binding protein gene microsatellite polymorphism influences BMD and risk of fractures in men.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2008Article
- Identification of a role for the ARHGEF3 gene in postmenopausal osteoporosis.American journal of human genetics · 2008Article
- In vivo genome-wide expression study on human circulating B cells suggests a novel ESR1 and MAPK3 network for postmenopausal osteoporosis.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2008Article
- A whole genome linkage scan for QTLs underlying peak bone mineral density.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2008Article
Corrections and comments
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Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOsteoporosis is a major public health problem, mainly quantified by low bone mineral density (BMD). The majority of BMD variation is determined by genetic effects. A pilot whole genome linkage scan (WGS) was previously reported in 53 white pedigrees with 630 subjects. Several genomic regions were suggested to be linked to BMD variation.
objectiveTo substantiate these previous findings and detect new genomic regions.
methodsA WGS was conducted on an extended sample where the size was almost tripled (1816 subjects from 79 pedigrees). All the subjects were genotyped with 451 microsatellite markers spaced approximately 8.1 cM apart across the human genome. Two point and multipoint linkage analyses were carried out using the variance component method.
resultsThe strongest linkage signal was obtained on Xq27 with two point LOD scores of 4.30 for wrist BMD, and 2.57 for hip BMD, respectively. Another important region was 11q23, which achieved a maximum LOD score of 3.13 for spine BMD in multipoint analyses, confirming the results on this region in two earlier independent studies. Suggestive linkage evidence was also found on 7p14 and 20p12.
conclusionsTogether with the findings from other studies, the current study has further delineated the genetic basis of bone mass and highlights the importance of increasing sample size to confirm linkage findings and to identify new regions of linkage.
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