ReviewJournal of medical genetics2004
Recent advances in understanding haemochromatosis: a transition state.
Review in Journal of medical genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 62 citations in OpenAlex.
- Correlation of hepcidin and serum ferritin levels in thalassemia patients at Chiang Mai University Hospital.Bioscience reports · 2021Article
- Juvenile Hemochromatosis, Genetic Study and Long-term Follow up after Therapy.Middle East journal of digestive diseases · 2014Article
- Iron overload in HFE C282Y heterozygotes at first genetic testing: a strategy for identifying rare HFE variants.Haematologica · 2011Article
- Investigation of the biophysical and cell biological properties of ferroportin, a multipass integral membrane protein iron exporter.Journal of molecular biology · 2009Article
- Increased susceptibility to Mycobacterium avium in hemochromatosis protein HFE-deficient mice.Infection and immunity · 2008Article
- Non-HFE haemochromatosis.World journal of gastroenterology · 2007Review
- Metabolic syndrome, insulin resistance and the inflammation markers C-reactive protein and ferritin.European journal of clinical nutrition · 2006Article
- The Q283P amino-acid change in HFE leads to structural and functional consequences similar to those described for the mutated 282Y HFE protein.Human genetics · 2005Article
- Hemojuvelin: a supposed role in iron metabolism one year after its discovery.Journal of molecular medicine (Berlin, Germany) · 2005Review
- Allele frequencies of hemojuvelin gene (HJV) I222N and G320V missense mutations in white and African American subjects from the general Alabama population.BMC medical genetics · 2004Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 1 institution in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mutations in the hepcidin gene HAMP and the hemojuvelin gene HJV have recently been shown to result in juvenile haemochromatosis (JH). Hepcidin is an antimicrobial peptide that plays a key role in regulating intestinal iron absorption. Hepcidin levels are reduced in patients with haemochromatosis due to mutations in the HFE and HJV genes. Digenic inheritance of mutations in HFE and HAMP can result in either JH or hereditary haemochromatosis (HH) depending upon the severity of the mutation in HAMP. Here we review these findings and discuss how understanding the different types of haemochromatosis and our increasing knowledge of iron metabolism may help to elucidate the host's response to infection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.