ArticleThe Journal of biological chemistry2004
Aldose reductase-catalyzed reduction of aldehyde phospholipids.
Article in The Journal of biological chemistry, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 65 citations in OpenAlex.
- Carnosine Supplementation Mitigates the Deleterious Effects of Particulate Matter Exposure in Mice.Journal of the American Heart Association · 2019Article
- Glucose Metabolism in Cardiac Hypertrophy and Heart Failure.Journal of the American Heart Association · 2019Review
- Measurement of Reactive Oxygen Species, Reactive Nitrogen Species, and Redox-Dependent Signaling in the Cardiovascular System: A Scientific Statement From the American Heart Association.Circulation research · 2016Review
- Oxidative and reductive metabolism of lipid-peroxidation derived carbonyls.Chemico-biological interactions · 2015Article
- Aldo-keto Reductase 1B15 (AKR1B15): a mitochondrial human aldo-keto reductase with activity toward steroids and 3-keto-acyl-CoA conjugates.The Journal of biological chemistry · 2015Article
- Lipid peroxidation generates biologically active phospholipids including oxidatively N-modified phospholipids.Chemistry and physics of lipids · 2014Review
- A potential therapeutic role for aldose reductase inhibitors in the treatment of endotoxin-related inflammatory diseases.Expert opinion on investigational drugs · 2012Review
- Aldose reductase regulates TNF-α-induced inducible nitric oxide synthase expression in human mesangial cells.Molecular biology reports · 2012Article
- Hydroxyalkenals and oxidized phospholipids modulation of endothelial cytoskeleton, focal adhesion and adherens junction proteins in regulating endothelial barrier function.Microvascular research · 2012Review
- Hyperglycemia and endothelial dysfunction in atherosclerosis: lessons from type 1 diabetes.International journal of vascular medicine · 2012Article
- Reductive metabolism increases the proinflammatory activity of aldehyde phospholipids.Journal of lipid research · 2011Article
- Human aldose reductase expression accelerates atherosclerosis in diabetic apolipoprotein E-/- mice.Arteriosclerosis, thrombosis, and vascular biology · 2011Article
- Functional expression of novel human and murine AKR1B genes.Chemico-biological interactions · 2011Article
- Catalytic reduction of carbonyl groups in oxidized PAPC by Kvβ2 (AKR6).Chemico-biological interactions · 2011Article
- Aldose reductase is a potent regulator of TGF-β1 induced expression of fibronectin in human mesangial cells.Molecular biology reports · 2010Article
- Generation and biological activities of oxidized phospholipids.Antioxidants & redox signaling · 2010Review
- Autoimmunity in membranous nephropathy targets aldose reductase and SOD2.Journal of the American Society of Nephrology : JASN · 2010Article
- Reductive metabolism of AGE precursors: a metabolic route for preventing AGE accumulation in cardiovascular tissue.Diabetes · 2009Article
- Aldose reductase protects against early atherosclerotic lesion formation in apolipoprotein E-null mice.Circulation research · 2009Article
- Aldose reductase decreases endoplasmic reticulum stress in ischemic hearts.Chemico-biological interactions · 2009Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Oxidation of unsaturated phospholipids results in the generation of aldehyde side chains that remain esterified to the phospholipid backbone. Such "core" aldehydes elicit immune responses and promote inflammation. However, the biochemical mechanisms by which phospholipid aldehydes are metabolized or detoxified are not well understood. In the studies reported here, we examined whether aldose reductase (AR), which reduces hydrophobic aldehydes, metabolizes phospholipid aldehydes. Incubation with AR led to the reduction of 5-oxovaleroyl, 7-oxo-5-heptenoyl, 5-hydroxy-6-oxo-caproyl, and 5-hydroxy-8-oxo-6-octenoyl phospholipids generated upon oxidation of 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (PAPC). The enzyme also catalyzed the reduction of phospholipid aldehydes generated from the oxidation of 1-alkyl, and 1-alkenyl analogs of PAPC, and 1-palmitoyl-2-arachidonoyl phosphatidic acid or phosphoglycerol. Aldose reductase catalyzed the reduction of chemically synthesized 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphatidylcholine (POVPC) with a K(m) of 10 mum. Addition of POVPC to the culture medium led to incorporation and reduction of the aldehyde in COS-7 and THP-1 cells. Reduction of POVPC in these cells was prevented by the AR inhibitors sorbinil and tolrestat and was increased in COS-7 cells overexpressing AR. Together, these observations suggest that AR may be a significant participant in the metabolism of several structurally diverse phospholipid aldehydes. This metabolism may be a critical regulator of the pro-inflammatory and immunogenic effects of oxidized phospholipids.
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