ArticleOphthalmology2004
Characteristic retinal atrophy with secondary "inverse" optic atrophy identifies vigabatrin toxicity in children.
Article in Ophthalmology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 100 citations in OpenAlex.
- Taurine deficiency is a cause of vigabatrin-induced retinal phototoxicity.Annals of neurology · 2009Trial
- Imaging the optic nerve with optical coherence tomography.Eye (London, England) · 2024Review
- Pharmacokinetics and tissue distribution of vigabatrin enantiomers in rats.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024Article
- Ocular examinations, findings, and toxicity in children taking vigabatrin.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2022Article
- Visual electrophysiology in the assessment of toxicity and deficiency states affecting the visual system.Eye (London, England) · 2021Review
- Infantile Spasms and West Syndrome - A Clinician's Perspective.Indian journal of pediatrics · 2020Review
- Reliability of Handheld Optical Coherence Tomography in Children Younger Than Three Years of Age Undergoing Vigabatrin Treatment for Childhood Epilepsy.Translational vision science & technology · 2020Article
- Vigabatrin-Induced Retinal Functional Alterations and Second-Order Neuron Plasticity in C57BL/6J Mice.Investigative ophthalmology & visual science · 2020Article
- Observational
- Evaluation of inner retinal layers with optic coherence tomography in vigabatrin-exposed patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017Article
- Optical coherence tomography measurements in compressive optic neuropathy associated with dysthyroid orbitopathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2016Article
- Vigabatrin can enhance electroretinographic responses in pigmented and albino rats.Documenta ophthalmologica. Advances in ophthalmology · 2015Article
- Vigabatrin retinal toxicity in children with infantile spasms: An observational cohort study.Neurology · 2014Observational
- Article
- Vigabatrin-induced retinal toxicity is partially mediated by signaling in rod and cone photoreceptors.PloS one · 2012Article
- Fundal changes in children receiving Vigabatrin.Indian journal of pediatrics · 2011Article
- Electroretinogram changes in a pediatric population with epilepsy: is vigabatrin acting alone?Journal of child neurology · 2011Article
- The safety and tolerability of newer antiepileptic drugs in children and adolescents.CNS drugs · 2010Review
- Taurine deficiency damages photoreceptors and retinal ganglion cells in vigabatrin-treated neonatal rats.Molecular and cellular neurosciences · 2010Article
- Reduced grating acuity associated with retinal toxicity in children with infantile spasms on vigabatrin therapy.Investigative ophthalmology & visual science · 2009Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo describe the clinical pattern of retinal atrophy in children caused by the anticonvulsant vigabatrin.
designAn interventional case series report.
participantsOne hundred thirty-eight patients, mainly infants, were evaluated regularly for evidence of possible vigabatrin toxicity in the Eye and Neurology clinics at the Hospital for Sick Children, Toronto.
methodSequential clinical and electroretinographic (International Society for Clinical Electrophysiology of Vision standards) evaluations every 6 months.
main outcome measuresPresence of recognizable retinal and optic atrophy in the presence of abnormal electroretinogram (ERG) and other clinical findings.
resultsThree children being treated for seizures with vigabatrin showed definite clinical findings of peripheral retinal nerve fiber layer atrophy, with relative sparing of the central or macular portion of the retina and relative nasal optic nerve atrophic changes. Some macular wrinkling was evident in 1 case. Progressive ERG changes showing decreased responses, especially the 30-Hz flicker response, supported the presence of decreased retinal function.
conclusionsA recognizable and characteristic form of peripheral retinal atrophy and nasal or "inverse" optic disc atrophy can occur in a small number of children being treated with vigabatrin. The changes in superficial light reflexes of the retina in children facilitate the clinical recognition of nerve fiber layer atrophy. The macula is relatively spared, although superficial retinal light reflexes indicating wrinkling of the innermost retina suggest early macular toxicity as well. Because these changes are accompanied by electrophysiologic evidence of retinal dysfunction, discontinuation of vigabatrin should be strongly considered.
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