Trial reportJournal of psychosomatic research2004
Mild acute inflammatory stimulation induces transient negative mood.
Trial report in Journal of psychosomatic research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 83 citations in OpenAlex.
- Effects of a mild inflammatory challenge on cytokines and sickness behavior: A randomized controlled trial using the influenza vaccine.Brain, behavior, and immunity · 2025Trial
- The Effects of Neuroinflammation Induced by Typhoid Vaccine on Resting and Task-Based Electroencephalography.Brain and behavior · 2025Trial
- Inflammation causes mood changes through alterations in subgenual cingulate activity and mesolimbic connectivity.Biological psychiatry · 2009Trial
- Neural origins of human sickness in interoceptive responses to inflammation.Biological psychiatry · 2009Trial
- Dispositional optimism and stress-induced changes in immunity and negative mood.Brain, behavior, and immunity · 2009Trial
- Synergistic effects of psychological and immune stressors on inflammatory cytokine and sickness responses in humans.Brain, behavior, and immunity · 2009Trial
- Transcriptome-informed brain cartography of polygenic risk and association with brain structure in major psychiatric disorders.Molecular psychiatry · 2026Article
- Inflammatory models of depression in rodents and humans.Frontiers in psychiatry · 2026Review
- Inflammatory reactivity to the influenza vaccine is associated with changes in automatic social behavior.Brain, behavior, and immunity · 2022Article
- Microglia in depression: current perspectives.Science China. Life sciences · 2021Review
- Dietary fibre and the gut-brain axis: microbiota-dependent and independent mechanisms of action.Gut microbiome (Cambridge, England) · 2021Review
- Stress, sex hormones, inflammation, and major depressive disorder: Extending Social Signal Transduction Theory of Depression to account for sex differences in mood disorders.Psychopharmacology · 2019Review
- The Neuroscience of Nonpharmacological Traditional Chinese Therapy (NTCT) for Major Depressive Disorder: A Systematic Review and Meta-Analysis.Evidence-based complementary and alternative medicine : eCAM · 2019Review
- Within-subject associations between inflammation and features of depression: Using the flu vaccine as a mild inflammatory stimulus.Brain, behavior, and immunity · 2018Article
- Possible association of Firmicutes in the gut microbiota of patients with major depressive disorder.Neuropsychiatric disease and treatment · 2018Article
- Parental support buffers the association of depressive symptoms with cortisol and C-reactive protein during adolescence.Brain, behavior, and immunity · 2016Article
- Stress, the Autonomic Nervous System, and the Immune-kynurenine Pathway in the Etiology of Depression.Current neuropharmacology · 2016Review
- Inflammatory cytokine-associated depression.Brain research · 2015Review
- From stress to inflammation and major depressive disorder: a social signal transduction theory of depression.Psychological bulletin · 2014Review
- Neuroinflammation and comorbidity of pain and depression.Pharmacological reviews · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aims to assess the mood changes induced by mild acute inflammatory stimulation (typhoid vaccination).
methodsUsing a double blind study design, 26 healthy volunteers underwent baseline assessments of mood, financial strain and work stress and were randomised to injection of Salmonella typhi vaccine or placebo injection. Mood, symptoms and body temperature was assessed by a modified version of the Profile of Mood States at 1, 2, 3, 4, 6 and 8 h post injection.
resultsTyphoid vaccination induces no increases in physical symptoms or temperature. Mood improved over the day in the placebo but not in the vaccine condition. Negative changes in mood following injection were correlated with chronic stress (financial strain) in the vaccination condition (r=-.65, P<.025).
conclusionA mild acute inflammatory stimulus induces transient negative mood, and responses were modulated by chronic stress. Implications for depressed mood in physical illness are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.