ReviewBrain research. Brain research reviews2004
Opioid research in amphibians: an alternative pain model yielding insights on the evolution of opioid receptors.
Review in Brain research. Brain research reviews, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 81 citations in OpenAlex.
- Genetic and functional analysis of a Pacific hagfish opioid system.Journal of neuroscience research · 2022Article
- Quantitative and Qualitative Behavioral Measurements to Assess Pain in Axolotls (Journal of the American Association for Laboratory Animal Science : JAALAS · 2020Article
- How evolutionary psychiatry can advance psychopharmacology .Dialogues in clinical neuroscience · 2019Article
- Comparison of Etomidate, Benzocaine, and MS222 Anesthesia with and without Subsequent Flunixin Meglumine Analgesia in African Clawed Frogs (Journal of the American Association for Laboratory Animal Science : JAALAS · 2018Article
- Current and Future Issues in the Development of Spinal Agents for the Management of Pain.Current neuropharmacology · 2017Review
- Is "cooling then freezing" a humane way to kill amphibians and reptiles?Biology open · 2015Article
- Effects of sciatic nerve transection on ultrastructure, NADPH-diaphorase reaction and serotonin-, tyrosine hydroxylase-, c-Fos-, glucose transporter 1- and 3-like immunoreactivities in frog dorsal root ganglion.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2013Article
- Analgesic effects of meloxicam, morphine sulfate, flunixin meglumine, and xylazine hydrochloride in African-clawed frogs (Xenopus laevis).Journal of the American Association for Laboratory Animal Science : JAALAS · 2011Article
- Analgesia in amphibians: preclinical studies and clinical applications.The veterinary clinics of North America. Exotic animal practice · 2011Review
- The effect of opioids and their antagonists on the nocifensive response of Caenorhabditis elegans to noxious thermal stimuli.Invertebrate neuroscience : IN · 2009Article
- Comparison of buprenorphine and butorphanol analgesia in the eastern red-spotted newt (Notophthalmus viridescens).Journal of the American Association for Laboratory Animal Science : JAALAS · 2009Article
- Nociceptin produces antinociception after spinal administration in amphibians.Pharmacology, biochemistry, and behavior · 2009Article
- The evolution of vertebrate opioid receptors.Frontiers in bioscience (Landmark edition) · 2009Review
- Evolution of vertebrate opioid receptors.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Emerging synergisms between drugs and physiologically-patterned weak magnetic fields: implications for neuropharmacology and the human population in the twenty-first century.Current neuropharmacology · 2007Article
- Systemic and spinal administration of the mu opioid, remifentanil, produces antinociception in amphibians.European journal of pharmacology · 2006Article
- Bremazocine: a kappa-opioid agonist with potent analgesic and other pharmacologic properties.CNS drug reviews · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
This review summarizes the work from our laboratory investigating mechanisms of opioid analgesia using the Northern grass frog, Rana pipiens. Over the last dozen years, we have accumulated data on the characterization of behavioral effects after opioid administration on radioligand binding by using opioid agonist and antagonist ligands in amphibian brain and spinal cord homogenates, and by cloning and sequencing opioid-like receptor cDNA from amphibian central nervous system (CNS) tissues. The relative analgesic potency of mu, delta, and kappa opioids is highly correlated between frogs and other mammals, including humans. Radioligand binding studies using selective opioid agonists show a similar selectivity profile in amphibians and mammals. In contrast, opioid antagonists that are highly selective for mammalian mu, delta, and kappa opioid receptors were not selective in behavioral and binding studies in amphibians. Three opioid-like receptor cDNAs were cloned and sequenced from amphibian brain tissues and are orthologs to mammalian mu, delta, and kappa opioid receptors. Bioinformatics analysis of the three types of opioid receptor cDNAs from all vertebrate species with full datasets gave a pattern of the molecular evolution of opioid receptors marked by the divergence of mu, delta, and kappa opioid receptor sequences during vertebrate evolution. This divergence in receptor amino acid sequence in later-evolved vertebrates underlies the hypothesis that opioid receptors are more type-selective in mammals than in nonmammalian vertebrates. The apparent order of receptor type evolution is kappa, then delta, and, most recently, the mu opioid receptor. Finally, novel bioinformatics analyses suggest that conserved extracellular receptor domains determine the type selectivity of vertebrate opioid receptors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.