ArticleThe Biochemical journal2005
Syncollin is required for efficient zymogen granule exocytosis.
Article in The Biochemical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- Endangered Steppe Eagle (ZooKeys · 2026Article
- Macrophage inhibitory cytokine 1, syncollin and thrombospondin-2 in pancreatic ductal adenocarcinoma and chronic pancreatitis differentiation.Frontiers in oncology · 2026Article
- The olfactory receptor Olfr78 promotes differentiation of enterochromaffin cells in the mouse colon.EMBO reports · 2024Article
- Specific Temporal Requirement of Prox1 Activity During Pancreatic Acinar Cell Development.Gastro hep advances · 2022Article
- Interleukin 22 disrupts pancreatic function in newborn mice expressing IL-23.Nature communications · 2019Article
- Convergent gene losses illuminate metabolic and physiological changes in herbivores and carnivores.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Pancreatic gene expression during recovery after pancreatitis reveals unique transcriptome profiles.Scientific reports · 2018Article
- Differential expression of pancreatic protein and chemosensing receptor mRNAs in NKCC1-null intestine.World journal of gastrointestinal pathophysiology · 2016Article
- Polymeric immunoglobulin receptor traffics through two distinct apically targeted pathways in primary lacrimal gland acinar cells.Journal of cell science · 2013Article
- Circadian rhythms of fetal liver transcription persist in the absence of canonical circadian clock gene expression rhythms in vivo.PloS one · 2012Article
- Replacement of Rbpj with Rbpjl in the PTF1 complex controls the final maturation of pancreatic acinar cells.Gastroenterology · 2010Article
- Keratin overexpression levels correlate with the extent of spontaneous pancreatic injury.The American journal of pathology · 2008Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Syncollin is a 13 kDa protein that is present in the exocrine pancreas, where the majority of the protein is tightly attached to the luminal surface of the zymogen granule membrane. We have addressed the physiological role of syncollin by studying the phenotype of syncollin KO (knockout) mice. These mice show pancreatic hypertrophy and elevated pancreatic amylase levels. Further, secretagogue-stimulated amylase release from pancreatic lobules of syncollin KO mice was found to be reduced by about 45% compared with wild-type lobules, and the delivery of newly synthesized protein to zymogen granules was delayed, indicating that the mice have a pancreatic secretory defect. As determined by two-photon imaging, the number of secretagogue-stimulated exocytotic events in acini from syncollin KO mice was reduced by 50%. This reduction was accounted for predominantly by a loss of later, 'secondary' fusion events between zymogen granules and other granules that had already fused with the plasma membrane. We conclude that syncollin is required for efficient exocytosis in the pancreatic acinar cell, and that it plays a particularly important role in compound exocytosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.