ArticleJournal of molecular evolution2004
The decline of isochores in mammals: an assessment of the GC content variation along the mammalian phylogeny.
Article in Journal of molecular evolution, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Article
- Phenolic constituents and modulatory effects of Raffia palm leaf (Journal of traditional and complementary medicine · 2017Article
- Evolutionary consequences of DNA methylation on the GC content in vertebrate genomes.G3 (Bethesda, Md.) · 2015Article
- Phenolic Extract from Moringa oleifera Leaves Inhibits Key Enzymes Linked to Erectile Dysfunction and Oxidative Stress in Rats' Penile Tissues.Biochemistry research international · 2015Article
- Evidence for GC-biased gene conversion as a driver of between-lineage differences in avian base composition.Genome biology · 2014Article
- Linking great apes genome evolution across time scales using polymorphism-aware phylogenetic models.Molecular biology and evolution · 2013Article
- Evolutionary diversification of the multimeric states of proteins.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Twisted signatures of GC-biased gene conversion embedded in an evolutionary stable karyotype.Molecular biology and evolution · 2013Article
- TPMS: a set of utilities for querying collections of gene trees.BMC bioinformatics · 2013Article
- Widespread recurrent evolution of genomic features.Genome biology and evolution · 2012Review
- Dynamic evolution of base composition: causes and consequences in avian phylogenomics.Molecular biology and evolution · 2011Article
- The Anolis lizard genome: an amniote genome without isochores.Genome biology and evolution · 2011Article
- The repatterning of eukaryotic genomes by random genetic drift.Annual review of genomics and human genetics · 2011Review
- Substitution patterns are under different influences in primates and rodents.Genome biology and evolution · 2011Article
- Contrasting GC-content dynamics across 33 mammalian genomes: relationship with life-history traits and chromosome sizes.Genome research · 2010Article
- A new framework for studying the isochore evolution: estimation of the equilibrium GC content based on the temporal mutation rate model.Genome biology and evolution · 2010Article
- Independent mammalian genome contractions following the KT boundary.Genome biology and evolution · 2009Article
- Effect of the assignment of ancestral CpG state on the estimation of nucleotide substitution rates in mammals.BMC evolutionary biology · 2008Article
- The opossum genome: insights and opportunities from an alternative mammal.Genome research · 2008Review
- The impact of recombination on nucleotide substitutions in the human genome.PLoS genetics · 2008Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Whether isochores, the large-scale variation of the GC content in mammalian genomes, are being maintained has recently been questioned. It has been suggested that GC-rich isochores originated in the ancestral amniote genome but that whatever force gave rise to them is no longer effective and that isochores are now disappearing from mammalian genomes. Here we investigated the evolution of the GC content of 41 coding genes in 6 to 66 species of mammals by estimating the ancestral GC content using a method which allows for different rates of substitution between sites. We found a highly significant decrease in the GC content during early mammalian evolution, as well as a weaker but still significant decrease in the GC content of GC-rich genes later in at least three groups of mammals: primates, rodents, and carnivores. These results are of interest because they confirm the recently suggested disappearance of GC-rich isochores in some mammalian genomes, and more importantly, they suggest that this disappearance started very early in mammalian evolution.
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