ArticleJournal of molecular evolution2004
Evidence for recombination in the microcystin synthetase (mcy) genes of toxic cyanobacteria Microcystis spp.
Article in Journal of molecular evolution, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 98 citations in OpenAlex.
- Evolutionary strategies of late-stage diversification in bacterial biosynthetic gene clusters.Essays in biochemistry · 2026Review
- Trade-off in genome turnover events leading to adaptive evolution of Microcystis aeruginosa species complex.BMC genomics · 2023Article
- Genotyping and Multivariate Regression Trees Reveal Ecological Diversification within the Microcystis aeruginosa Complex along a Wide Environmental Gradient.Applied and environmental microbiology · 2022Article
- Review
- Potentially Toxic Planktic and Benthic Cyanobacteria in Slovenian Freshwater Bodies: Detection by Quantitative PCR.Toxins · 2021Article
- Coherence of Microcystis species revealed through population genomics.The ISME journal · 2019Article
- The Biosynthesis of Rare Homo-Amino Acid Containing Variants of Microcystin by a Benthic Cyanobacterium.Marine drugs · 2019Article
- Multiple Stressors at the Land-Sea Interface: Cyanotoxins at the Land-Sea Interface in the Southern California Bight.Toxins · 2017Article
- Polysaccharide biosynthesis-related genes explain phenotype-genotype correlation of Microcystis colonies in Meiliang Bay of Lake Taihu, China.Scientific reports · 2016Article
- Genetic characterization of Microcystis aeruginosa isolates from Portuguese freshwater systems.World journal of microbiology & biotechnology · 2016Article
- Review
- Evolution of the tRNALeu (UAA) Intron and Congruence of Genetic Markers in Lichen-Symbiotic Nostoc.PloS one · 2015Article
- Next-generation sequencing (NGS) for assessment of microbial water quality: current progress, challenges, and future opportunities.Frontiers in microbiology · 2015Review
- Convergent evolution of [D-Leucine(1)] microcystin-LR in taxonomically disparate cyanobacteria.BMC evolutionary biology · 2013Article
- Phylogeny of microcystins: evidence of a biogeographical trend?Current microbiology · 2013Article
- Gene flow, recombination, and selection in cyanobacteria: population structure of geographically related Planktothrix freshwater strains.Applied and environmental microbiology · 2013Article
- Molecular evaluation on the distribution, diversity, and toxicity of Microcystis (Cyanobacteria) species from Lake Ulungur--a mesotrophic brackish desert lake in Xinjiang, China.Environmental monitoring and assessment · 2011Article
- Local expansion of a panmictic lineage of water bloom-forming cyanobacterium Microcystis aeruginosa.PloS one · 2011Article
- Diversity of cyanobacterial phylotypes in a Mediterranean drinking water reservoir (Marathonas, Greece).Environmental monitoring and assessment · 2011Article
- Detection of microcystin-producing cyanobacteria in Missisquoi Bay, Quebec, Canada, using quantitative PCR.Applied and environmental microbiology · 2010Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recombination has been suggested to be an important factor for the genetic variation of bacterial genes, but few studies have dealt with intragenic recombination between the same or closely related species of cyanobacteria. Here we provide strong evidence for recombination in the microcystin synthetase (mcy) gene cluster of the toxic cyanobacteria Microcystis spp. This gene cluster contains 10 genes (mcyA to J) that encode a mixed polyketide synthase (PKS)/nonribosomal peptide synthetase (NRPS) complex. mcy gene sequences were determined for four selected regions (within mcyA, D, G, and J) within the mcy gene cluster from 1 Canadian and 10 Asian toxic Microcystis and compared with previously published mcy sequences. Split decomposition analysis indicated a reticulate phylogeny of mcyA, and several potential recombination tracts of mcyA were identified by the RDP analysis and a runs test implemented in GENECONV. In contrast, no recombination was detected in the mcyD, G, and J sequences. However, discrepancies among the four mcy gene genealogies were evident from the results of independent split decomposition analyses, which were further supported by incongruence length difference (ILD) tests. Taken together, these findings suggest that both intragenic and intergenic recombination within the mcy gene cluster contributes to the genetic diversity of the mcy genes of Microcystis spp.
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