ArticleThe Journal of physiology2004
The effect of simulated ischaemia on spontaneous GABA release in area CA1 of the juvenile rat hippocampus.
Article in The Journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
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- VEGF ameliorates cognitive impairment in in vivo and in vitro ischemia via improving neuronal viability and function.Neuromolecular medicine · 2014Article
- Characterization of inhibitory GABA-A receptor activation during spreading depolarization in brain slice.PloS one · 2014Article
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- Bestrophin1 Channels are Insensitive to Ethanol and Do not Mediate Tonic GABAergic Currents in Cerebellar Granule Cells.Frontiers in neuroscience · 2011Article
- Vesicular GABA release delays the onset of the Purkinje cell terminal depolarization without affecting tissue swelling in cerebellar slices during simulated ischemia.Neuroscience · 2010Article
- Enhancement of inhibitory synaptic transmission in large aspiny neurons after transient cerebral ischemia.Neuroscience · 2009Article
- Tamoxifen mediated estrogen receptor activation protects against early impairment of hippocampal neuron excitability in an oxygen/glucose deprivation brain slice ischemia model.Brain research · 2009Article
- Resveratrol attenuates early pyramidal neuron excitability impairment and death in acute rat hippocampal slices caused by oxygen-glucose deprivation.Experimental neurology · 2008Article
- Spiking and nonspiking classes of oligodendrocyte precursor glia in CNS white matter.Nature neuroscience · 2008Article
- Androgens predispose males to GABAA-mediated excitotoxicity in the developing hippocampus.Experimental neurology · 2008Article
- Neurotransmitter depletion by bafilomycin is promoted by vesicle turnover.Neuroscience letters · 2007Article
- The electrical response of cerebellar Purkinje neurons to simulated ischaemia.Brain : a journal of neurology · 2005Article
- Tonic release of glutamate by a DIDS-sensitive mechanism in rat hippocampal slices.The Journal of physiology · 2005Article
- A preferential role for glycolysis in preventing the anoxic depolarization of rat hippocampal area CA1 pyramidal cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An early consequence of brain energy deprivation is an increase in the frequency of spontaneous inhibitory and excitatory postsynaptic currents (sIPSCs and sEPSCs), which may disrupt neural information processing. This increase in spontaneous transmitter release has been reported to occur in calcium-free solution and has been attributed either to calcium release from internal stores or to a direct effect of hypoxia on the transmitter release mechanism. Here we investigate the mechanism of the increase in sIPSC frequency that occurs in area CA1 of rat hippocampus during simulated ischaemia, by making patch-clamp recordings from CA1 pyramidal neurones. When recording in whole-cell mode, exposure to ischaemic solution increased the sIPSC frequency 30-fold (to 49 Hz) after 5 min, and doubled the sIPSC amplitude. Ischaemic sIPSCs were action potential independent, vesicular in origin and, contrary to the results of earlier studies which did not buffer extracellular calcium to a low level, dependent on extracellular calcium. The properties of the ischaemic sIPSCs were not affected by depleting intracellular stores of calcium or by blocking the neuronal GABA transporter GAT-1. Recording from neurones using gramicidin-perforated patch-clamping showed a 10-fold smaller, more transient increase in sIPSC frequency during ischaemia, with no change of sIPSC amplitude, suggesting that whole-cell clamp recording increases the ischaemia-induced sIPSC rate and amplitude by controlling the intracellular milieu.
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