ArticleMolecular and cellular biology1992
MEI4, a meiosis-specific yeast gene required for chromosome synapsis.
Article in Molecular and cellular biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 55 citations in OpenAlex.
- Mei4 deficiency induces sexual dimorphism in early meiosis and promotes production of unreduced eggs in zebrafish.Zoological research · 2026Article
- The B-type cyclin Clb4 prevents meiosis I sister centromere separation in budding yeast.G3 (Bethesda, Md.) · 2025Article
- Tethering recombination initiation proteins in Saccharomyces cerevisiae promotes double strand break formation.Genetics · 2009Article
- Chromatin remodeling finds its place in the DNA double-strand break response.Nucleic acids research · 2009Review
- High-density yeast-tiling array reveals previously undiscovered introns and extensive regulation of meiotic splicing.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- The cellular control of DNA double-strand breaks.Journal of cellular biochemistry · 2006Review
- Thermoconditional modulation of the pleiotropic sensitivity phenotype by the Saccharomyces cerevisiae PRP19 mutant allele pso4-1.Nucleic acids research · 2002Article
- Characterization of rec7, an early meiotic recombination gene in Schizosaccharomyces pombe.Genetics · 2001Article
- Test of intron predictions reveals novel splice sites, alternatively spliced mRNAs and new introns in meiotically regulated genes of yeast.Nucleic acids research · 2000Article
- Splicing of the meiosis-specific HOP2 transcript utilizes a unique 5' splice site.Molecular and cellular biology · 1999Article
- Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae.Microbiology and molecular biology reviews : MMBR · 1999Review
- Coordination of the initiation of recombination and the reductional division in meiosis in Saccharomyces cerevisiae.Genetics · 1999Article
- Meiotic recombination hotspots: shaping the genome and insights into hypervariable minisatellite DNA change.Current topics in developmental biology · 1998Review
- Identification of a new class of negative regulators affecting sporulation-specific gene expression in yeast.Genetics · 1997Article
- mre11S--a yeast mutation that blocks double-strand-break processing and permits nonhomologous synapsis in meiosis.Genes & development · 1997Article
- Article
- The synaptonemal complex--the chaperone of crossing over.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 1996Article
- The location and structure of double-strand DNA breaks induced during yeast meiosis: evidence for a covalently linked DNA-protein intermediate.The EMBO journal · 1995Article
- A DNA binding factor (UBF) interacts with a positive regulatory element in the promoters of genes expressed during meiosis and vegetative growth in yeast.Nucleic acids research · 1995Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The MEI4 gene product is required for meiotic induction of recombination and viable spore production in the yeast Saccharomyces cerevisiae. DNA sequence analysis shows that the MEI4 gene encodes a 450-amino-acid protein bearing no homology to any previously identified protein. The MEI4 coding region is interrupted by a small intron located near the 5' end of the gene. Efficient splicing of the MEI4 transcript is not dependent on the MER1 protein, which is required for splicing the transcript of another meiotic gene, MER2. Expression of a mei4::lacZ fusion gene is meiosis-specific and depends on both heterozygosity at the mating-type locus and nutrient limitation. Northern (RNA) blot hybridization analysis suggests that MEI4 gene expression is regulated at the level of transcription. A functional MEI4 gene is not required for meiotic induction of transcription of the MER1, MER2, MEK1, RED1, SPO11, or RAD50 gene. Cytological analysis of mei4 mutant strains during meiotic prophase demonstrates that the chromosomes form long axial elements that fail to undergo synapsis. The meiosis II division is delayed in mei4 strains.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.