Trial reportJournal of physiology and biochemistry2004
Daily ingestion of fermented milk containing Lactobacillus casei DN114001 improves innate-defense capacity in healthy middle-aged people.
Trial report in Journal of physiology and biochemistry, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.
- The effect of bovine dairy products and their components on the incidence and natural history of infection: a systematic literature review.Nutrition journal · 2024Pooled it
- Influence of a probiotic Lactobacillus casei strain on the colonisation with potential pathogenic streptococci and Staphylococcus aureus in the nasopharyngeal space of healthy men with a low baseline NK cell activity.Medical microbiology and immunology · 2015Trial
- Interleukin-12 is involved in the enhancement of human natural killer cell activity by Lactobacillus casei Shirota.Clinical and experimental immunology · 2006Trial
- A Meta-analysis of the Effect of ProbioticMedeniyet medical journal · 2024Article
- Evaluation of immunomodulatory potential of probiotic conditioned medium on murine macrophages.Scientific reports · 2024Article
- K-Ras Peptide Mimotope Induces Antigen Specific Th1 and B-Cell Immune Responses against G12A-Mutated K-Ras Antigen in Balb/c Mice.Vaccines · 2021Article
- Importance of Dietary Changes During the Coronavirus Pandemic: How to Upgrade Your Immune Response.Frontiers in public health · 2020Review
- Selected prebiotics and synbiotics administered in ovo can modify innate immunity in chicken broilers.BMC veterinary research · 2019Article
- A review of probiotic supplementation in healthy adults: helpful or hype?European journal of clinical nutrition · 2019Review
- Nutritional Modulation of Immune Function: Analysis of Evidence, Mechanisms, and Clinical Relevance.Frontiers in immunology · 2018Review
- The role of nutrition in enhancing immunity in aging.Aging and disease · 2012Article
- Modern approaches in probiotics research to control foodborne pathogens.Advances in food and nutrition research · 2012Review
- Effects of the oral administration of viable and heat-killed Streptococcus bovis HC5 cells to pre-sensitized BALB/c mice.PloS one · 2012Article
- Probiotics and immunity.Journal of gastroenterology · 2009Review
- Probiotics and small bowel mucosa: Molecular aspects of their interactions.Genes & nutrition · 2006Article
- Natural killer cell activities of synbiotic Lactobacillus casei ssp. casei in conjunction with dextran.Clinical and experimental immunology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Different lactic acid bacteria have often been administered as a dietary means to enhance immune system activity. Based on this statement, the aim of the current work was to test the effects of a Lactobacillus casei DN114001 fermented milk consumption on the immune response capacity in middle-age volunteers. Forty-five healthy volunteers, 24 women and 21 men (aged: 51-58 years), were randomized into two groups to receive three cups per day of a L. casei DN114001 (10(8)-10(10) ufc/g) fermented milk (n = 23), or placebo (n = 22), during an 8-week period. Measurements were performed before (day 0), and after the nutritional intervention (day 56). After the trial, no changes in immune cell proportions were detected, but the probiotic-treated group increased oxidative burst capacity of monocytes (probiotic group: p = 0.029; placebo group: p = 0.625), as well as NK cells tumoricidal activity (probiotic group: p = 0.023; placebo group: p = 0.125). Results showed that daily intake of fermented milk containing Lactobacillus casei DN114001 could have a positive effect in modulating the innate immune defense in healthy-middle-age people.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.