ArticleWorld journal of gastroenterology2004
Protective effects of tumor necrosis factor alpha antibody and ulinastatin on liver ischemic reperfusion in rats.
Article in World journal of gastroenterology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Hepatic ischemia-reperfusion injury with respect to oxidative stress and inflammatory response: a narrative review.Journal of Yeungnam medical science · 2023Article
- Article
- Preparation and characterization of a fully human monoclonal antibody specific for human tumor necrosis factor alpha.Bioengineered · 2021Article
- Effects of hypothermia on inflammatory cytokine expression in rat liver following asphyxial cardiac arrest.Experimental and therapeutic medicine · 2021Article
- miR-509 suppresses brain metastasis of breast cancer cells by modulating RhoC and TNF-α.Oncogene · 2015Article
- Hepatoprotective effect of ulinastatin in a rat model of major hepatectomy after obstructive jaundice.Digestive diseases and sciences · 2015Article
- Inhibition of tumor necrosis factor alpha reduces the outgrowth of hepatic micrometastasis of colorectal tumors in a mouse model of liver ischemia-reperfusion injury.Journal of biomedical science · 2014Article
- Ulinastatin preconditioning attenuates inflammatory reaction of hepatic ischemia reperfusion injury in rats via high mobility group box 1(HMGB1) inhibition.International journal of medical sciences · 2014Article
- Intraportal versus Systemic Pentoxifylline Infusion after Normothermic Liver Ischemia: Effects on Regional Blood Flow Redistribution and Hepatic Ischemia-Reperfusion Injury.HPB surgery : a world journal of hepatic, pancreatic and biliary surgery · 2013Article
- Inhibition of TNF-α protects against hepatic ischemia-reperfusion injury in rats via NF-κB dependent pathway.Naunyn-Schmiedeberg's archives of pharmacology · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study the protective effects of tumor necrosis factor alpha (TNF alpha) antibody and ulinastatin on liver ischemic reperfusion in rats.
methodsOne hundred and twenty male SD rats were randomly divided into four groups: normal control group, ischemic group, TNF alpha antibody group and TNF alpha antibody + ulinastatin group. The animals were killed at 0, 3, 6, 9, 12 h after ischemia for 60 min and followed by reperfusion. Serum alanine aminotransferase (ALT), malondialdehyde (MDA) and liver histopathology were observed.
resultsAfter ischemic reperfusion, the serum ALT and MDA were remarkably increased, and the hepatic congestion was obvious. Treatment of TNF alpha antibody and ulinastatin could significantly decrease serum ALT and MDA levels, and relieve hepatic congestion.
conclusionUlinastatin and TNF alpha antibody can suppress the inflammatory reaction induced by hepatic ischemic reperfusion, and have protective effects on rat hepatic ischemic reperfusion injury.
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