ArticleWorld journal of gastroenterology2004
Expression of survivin in primary and metastatic gastric cancer cells obtained by laser capture microdissection.
Article in World journal of gastroenterology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Role of survivin as prognostic and clinicopathological marker in gastric cancer: a meta-analysis.Molecular biology reports · 2013Pooled it
- Evaluation of Immunohistochemical Expression of Survivin and its Correlation with qRT-PCR Results as a Useful Diagnostic Marker in Gastric Cancer.Iranian journal of public health · 2024Article
- Prognostic Significance of p27 and Survivin in H. pylori Gastritis and Gastric Cancer.Asian Pacific journal of cancer prevention : APJCP · 2021Article
- Expression and clinical correlation of Survivin and PTEN in gastric cancer patients.Oncology letters · 2020Article
- Differentially localized survivin and STAT3 as markers of gastric cancer progression: Association with Helicobacter pylori.Cancer reports (Hoboken, N.J.) · 2018Observational
- Down-regulation of survivin suppresses uro-plasminogen activator through transcription factor JunB.Experimental & molecular medicine · 2011Article
- The association between the survivin C-31G polymorphism and gastric cancer risk in a Chinese population.Digestive diseases and sciences · 2009Article
- Significance of Survivin and PTEN expression in full lymph node-examined gastric cancer.World journal of gastroenterology · 2006Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimSurvivin, a recently identified member of the inhibitor of apoptosis protein family, is expressed during development and in various human cancers. However, its expression in normal tissues and clinical relevance in cancers are still debated. In the present study, we analyzed the expression of the survivin gene in human primary and metastatic gastric cancer cells as well as in paired epithelial cells from normal gastric mucosa by means of a novel laser capture microdissection (LCM) technique coupled with reverse transcription-polymerase chain reaction (RT-PCR).
methodsThirty patients who had undergone gastrectomy with lymph node dissection for gastric cancer without preoperative treatments were included. Neoplastic tissue, metastatic lymph nodes, and apparently uninvolved normal tissue were collected from each patient. LCM-captured "pure" cell groups were respectively subjected to RT-PCR analysis with primers specific for the survivin gene.
resultsOf the paired samples from 30 gastric cancer patients studied, 24 (80%) primary gastric cancer cell groups and 7 (23%) adjacent morphologically "normal" gastric epithelial cell groups were shown to have a detectable survivin expression. There was a statistically significant difference in suvivin expression between these two groups (P<0.01). Meanwhile, 95% (19/20) of the metastatic gastric cancer cell groups from lymph nodes had a clear expression of te survivin gene. However, no significant correlation between survivin expression and clinicopathological features of gastric cancer was observed in the present study.
conclusionSurvivin expression is present in the majority of gastric cancer cell groups obtained by LCM techniques. The high expression rate in metastatic lesions suggests a possible role of survivin in cancer invasiveness and metastasis. It may contribute to the detection of gastric cancer micrometastasis as a potential molecular marker. In addition, the high expression percentage renders survivin a potential target in the therapy for gastric cancer.
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