ArticleMammalian genome : official journal of the International Mammalian Genome Society2004
QTLs for pre- and postweaning body weight and body composition in selected mice.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Independent evolution toward larger body size in the distinctive Faroe Island mice.G3 (Bethesda, Md.) · 2021Pooled it
- Age-dependent genetic architecture across ontogeny of body size in sticklebacks.Proceedings. Biological sciences · 2022Article
- Application of bio-orthogonal proteome labeling to cell transplantation and heterochronic parabiosis.Nature communications · 2017Article
- Genetics of Rapid and Extreme Size Evolution in Island Mice.Genetics · 2015Article
- Genetic interactions with sex make a relatively small contribution to the heritability of complex traits in mice.PloS one · 2014Article
- Genetic determinants for intramuscular fat content and water-holding capacity in mice selected for high muscle mass.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Article
- Intersubspecific subcongenic mouse strain analysis reveals closely linked QTLs with opposite effects on body weight.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Article
- Mapping main, epistatic and sex-specific QTL for body composition in a chicken population divergently selected for low or high growth rate.BMC genomics · 2010Article
- Genetic variation in the pleiotropic association between physical activity and body weight in mice.Genetics, selection, evolution : GSE · 2009Article
- Relative contribution of additive, dominance, and imprinting effects to phenotypic variation in body size and growth between divergent selection lines of mice.Evolution; international journal of organic evolution · 2009Article
- Genetic factors contributing to obesity and body weight can act through mechanisms affecting muscle weight, fat weight, or both.Physiological genomics · 2009Article
- Article
- Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion.Endocrinology · 2008Article
- Genetic loci affecting body weight and fatness in a C57BL/6J x PWK/PhJ mouse intercross.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
- A growth QTL (Pbwg1) region of mouse chromosome 2 contains closely linked loci affecting growth and body composition.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
- Differentially expressed genes in adipose tissues of high body weight-selected (obese) and unselected (lean) mouse lines.Journal of applied genetics · 2007Article
- Identification of quantitative trait loci affecting body composition in a mouse intercross.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Quantitative trait loci for body size components in mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2006Article
- Article
- Bayesian analyses of multiple epistatic QTL models for body weight and body composition in mice.Genetical research · 2006Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In an intercross between the high-body-weight-selected mouse line NMRI8 and the inbred line DBA/2, we analyzed genetic effects on growth during the suckling period and after weaning during the juvenile phase of development. QTL mapping results indicated that a switch of gene activation might occur at the age of three weeks when animals are weaned. We found QTLs for body weight with major effects at the age of two and three weeks when animals are fed by their mothers, and QTLs with highest effects after weaning when animals have to live on their own under ad libitum access to food. Specific epistatic effects on body weight at two and three weeks and epistatic interaction influencing growth after weaning support this finding. QTL effects explained the greatest variance during puberty when animals grow fastest and become fertile. In the present study, all except one QTL effect for early body weight had dominance variance components. These might result from direct single-locus-dominant allelic expression, but also from the identified epistatic interaction between different QTLs that we have found for body weight at all ages. Beside body weight, body composition traits (muscle weight, reproductive fat weight, weight of inner organs) were analyzed. Sex-dimorphic QTLs were found for body weight and fat deposition. The identified early-growth QTLs could be the target of epigenetic modifications which might influence body weight at later ages.
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Registered trials
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