ArticleThe EMBO journal2004
The Rb tumor suppressor is required for stress erythropoiesis.
Article in The EMBO journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 92 citations in OpenAlex.
- Mitochondrial regulation of erythropoiesis in homeostasis and disease.British journal of haematology · 2024Review
- Rasa3 regulates stage-specific cell cycle progression in murine erythropoiesis.Blood cells, molecules & diseases · 2021Article
- Review
- Rbf Activates the Myogenic Transcriptional Program to Promote Skeletal Muscle Differentiation.Cell reports · 2019Article
- E2F-2 Promotes Nuclear Condensation and Enucleation of Terminally Differentiated Erythroblasts.Molecular and cellular biology · 2017Article
- Evaluating Effects of Hypomorphic Thoc1 Alleles on Embryonic Development in Rb1 Null Mice.Molecular and cellular biology · 2016Article
- Repression by RB1 characterizes genes involved in the penultimate stage of erythroid development.Cell cycle (Georgetown, Tex.) · 2015Article
- Article
- Translational control by heme-regulated eIF2α kinase during erythropoiesis.Current opinion in hematology · 2014Review
- Article
- Article
- Challenging the axiom: does the occurrence of oncogenic mutations truly limit cancer development with age?Oncogene · 2013Review
- Endothelial cell dysfunction and cytoskeletal changes associated with repression of p16(INK4a) during immortalization.Oncogene · 2012Article
- Heme-regulated eIF2α kinase activated Atf4 signaling pathway in oxidative stress and erythropoiesis.Blood · 2012Article
- Concomitant inactivation of Rb and E2f8 in hematopoietic stem cells synergizes to induce severe anemia.Blood · 2012Article
- p38α controls erythroblast enucleation and Rb signaling in stress erythropoiesis.Cell research · 2012Article
- Article
- Normal and disordered reticulocyte maturation.Current opinion in hematology · 2011Review
- p53, Stem Cells, and Reprogramming: Tumor Suppression beyond Guarding the Genome.Genes & cancer · 2011Article
- RB1, development, and cancer.Current topics in developmental biology · 2011Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
The retinoblastoma tumor suppressor gene plays important roles in cell cycle control, differentiation and survival during development and is functionally inactivated in most human cancers. Early studies using gene targeting in mice suggested a critical role for pRb in erythropoiesis, while more recent experiments have suggested that many of the abnormal embryonic phenotypes in the Rb null mouse result from a defective placenta. To address this controversy and determine whether Rb has cell intrinsic functions in erythropoiesis, we examined the effects of Rb loss on red cell production following acute deletion of pRb in vitro and under different stress conditions in vivo. Under stress conditions, pRb was required to regulate erythroblast expansion and promote red cell enucleation. Acute deletion of Rb in vitro induced erythroid cell cycle and differentiation defects similar to those observed in vivo. These results demonstrate a cell intrinsic role for pRb in stress erythropoiesis and hematopoietic homeostasis that has relevance for human diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.