Evidence map›Paper›PMID 15456940›Full record

ArticleJournal of molecular neuroscience : MN2004

The splicing regulatory protein p18SRP is down-regulated in Alzheimer's disease brain.

Klaus Heese, Masako Fujita, Hiroyasu Akatsu, Takayuki Yamamoto, Kenji Kosaka, Yasuo Nagai, Tohru Sawada

Abstract read
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In one paragraph

Article in Journal of molecular neuroscience : MN, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Klaus HeeseBF Research Institute, c/o National Cardiovascular Center, Suita, Osaka 565-0873, Japan. heesek@silver.ocn.ne.jp
Masako Fujita
Hiroyasu Akatsu
Takayuki Yamamoto
Kenji Kosaka
Yasuo Nagai
Tohru Sawada
National Cerebral and Cardiovascular Center · JPFukushimura Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is the most common neurodegenerative disorder of aging, accounting for an estimated two-thirds of all cases of senile dementia. Using bioinformatics, the yeast two-hybrid-system, reverse transcription polymerase chain reaction, and fluorescence microscopy analysis, we demonstrate here that the new putative splicing regulatory protein p18SRP is a lysine-rich zinc finger domain-containing protein that interacts with the serine-arginine (SR)-rich splicing regulatory protein SRrp86. The additional finding of its down-regulation in the brain of AD subjects points to a possible pivotal role of p18SRP in the control of cellular survival.

Indexed as

Down-RegulationRNA SplicingAgedAged, 80 and overAlzheimer DiseaseAmino Acid SequenceAnimalsBrainCell LineFemaleHumansMaleMolecular Sequence DataNuclear ProteinsRatsRecombinant Fusion ProteinsNuclear ProteinsRecombinant Fusion ProteinsRNA-Binding ProteinsSerine-Arginine Splicing FactorsSREK1IP1 protein, humanSrek1ip1 protein, ratSREK1 protein, human

Identifiers

PMID15456940
OpenAlexW2072177357

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.