ArticleMolecular and cellular biology2004
p55, the Drosophila ortholog of RbAp46/RbAp48, is required for the repression of dE2F2/RBF-regulated genes.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 68 citations in OpenAlex.
- Clinical and genetic characterization of a progressive RBL2-associated neurodevelopmental disorder.Brain : a journal of neurology · 2025Article
- RebL1 is required for macronuclear structure stability and gametogenesis inMarine life science & technology · 2024Article
- RBBP4 is an epigenetic barrier for the induced transition of pluripotent stem cells into totipotent 2C-like cells.Nucleic acids research · 2023Article
- Structure and function of MuvB complexes.Oncogene · 2022Review
- The MuvB complex binds and stabilizes nucleosomes downstream of the transcription start site of cell-cycle dependent genes.Nature communications · 2022Article
- Functional characterization of RebL1 highlights the evolutionary conservation of oncogenic activities of the RBBP4/7 orthologue in Tetrahymena thermophila.Nucleic acids research · 2021Article
- The multifaceted histone chaperone RbAp46/48 in Plasmodium falciparum: structural insights, production, and characterization.Parasitology research · 2020Article
- Loss of the Caenorhabditis elegans pocket protein LIN-35 reveals MuvB's innate function as the repressor of DREAM target genes.PLoS genetics · 2017Article
- A Src inhibitor regulates the cell cycle of human pluripotent stem cells and improves directed differentiation.The Journal of cell biology · 2015Article
- Arabidopsis thaliana MSI4/FVE associates with members of a novel family of plant specific PWWP/RRM domain proteins.Plant molecular biology · 2015Article
- The pro-apoptotic activity of Drosophila Rbf1 involves dE2F2-dependent downregulation of diap1 and buffy mRNA.Cell death & disease · 2014Article
- dREAM co-operates with insulator-binding proteins and regulates expression at divergently paired genes.Nucleic acids research · 2014Article
- The DREAM complex: master coordinator of cell cycle-dependent gene expression.Nature reviews. Cancer · 2013Review
- The complex containing Drosophila Myb and RB/E2F2 regulates cytokinesis in a histone H2Av-dependent manner.Molecular and cellular biology · 2013Article
- Msi1-Like (MSIL) Proteins in Fungi.Mycobiology · 2013Article
- Recognition of methylated peptides by Drosophila melanogaster polycomb chromodomain.Journal of proteome research · 2013Article
- Pleiotropic roles of the Msi1-like protein Msl1 in Cryptococcus neoformans.Eukaryotic cell · 2012Article
- A dual role for the dREAM/MMB complex in the regulation of differentiation-specific E2F/RB target genes.Molecular and cellular biology · 2012Article
- The enhancer of trithorax and polycomb gene Caf1/p55 is essential for cell survival and patterning in Drosophila development.Development (Cambridge, England) · 2011Article
- Drosophila SIN3 isoforms interact with distinct proteins and have unique biological functions.The Journal of biological chemistry · 2010Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Many proteins have been proposed to be involved in retinoblastoma protein (pRB)-mediated repression, but it is largely uncertain which cofactors are essential for pRB to repress endogenous E2F-regulated promoters. Here we have taken advantage of the stream-lined Drosophila dE2F/RBF pathway, which has only two E2Fs (dE2F1 and dE2F2), and two pRB family members (RBF1 and RBF2). With RNA interference (RNAi), we depleted potential corepressors and looked for the elevated expression of groups of E2F target genes that are known to be directly regulated by RBF1 and RBF2. Previous studies have implicated histone deacetylase (HDAC) and SWI/SNF chromatin-modifying complexes in pRB-mediated repression. However, our results fail to support the idea that the SWI/SNF proteins are required for RBF-mediated repression and suggest that a requirement for HDAC activities is likely to be limited to a subset of targets. We found that the chromatin assembly factor p55/dCAF-1 is essential for the repression of dE2F2-regulated targets. The removal of p55 deregulated the expression of E2F targets that are normally repressed by dE2F2/RBF1 and dE2F2/RBF2 complexes in a cell cycle-independent manner but had no effect on the expression of E2F targets that are normally coupled with cell proliferation. The results indicate that the mechanisms of RBF regulation at these two types of E2F targets are different and suggest that p55, and perhaps p55's mammalian orthologs RbAp46 and RbAp48, have a conserved function in repression by pRB-related proteins.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.