ArticleMolecular and cellular biology2004
Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
What it found
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Who cites it
57 citing papers in PubMed, 120 citations in OpenAlex.
- PTP4A2 promotes leukemogenesis through inhibiting the p53 tumor suppressor signaling pathway in leukemia-initiating cells.Blood advances · 2026Article
- Dependence on Mdm2 for Mdm4 inhibition of p53 activity.Cancer letters · 2025Article
- A Sub-Group of Kidney-Transplant Recipients with Highly Aggressive Squamous Cell Carcinoma Expressing Phosphorylated Serine392p53.International journal of molecular sciences · 2024Article
- Rapid and precise genotyping of transgene zygosity in mice using an allele-specific method.Life science alliance · 2023Article
- Deciphering the PTM codes of the tumor suppressor p53.Journal of molecular cell biology · 2022Review
- Differential p53-Mediated Cellular Responses to DNA-Damaging Therapeutic Agents.International journal of molecular sciences · 2021Review
- Genomic gain ofScience advances · 2021Article
- Regulating tumor suppressor genes: post-translational modifications.Signal transduction and targeted therapy · 2020Review
- Understanding p53 functions through p53 antibodies.Journal of molecular cell biology · 2019Review
- Evidence for allosteric effects on p53 oligomerization induced by phosphorylation.Protein science : a publication of the Protein Society · 2018Article
- Serine 392 phosphorylation modulates p53 mitochondrial translocation and transcription-independent apoptosis.Cell death and differentiation · 2018Article
- The Tail That Wags the Dog: How the Disordered C-Terminal Domain Controls the Transcriptional Activities of the p53 Tumor-Suppressor Protein.Trends in biochemical sciences · 2016Review
- Ultraviolet Radiation-Induced Skin Aging: The Role of DNA Damage and Oxidative Stress in Epidermal Stem Cell Damage Mediated Skin Aging.Stem cells international · 2016Review
- p53/p63/p73 in the epidermis in health and disease.Cold Spring Harbor perspectives in medicine · 2014Review
- Mutant TP53 posttranslational modifications: challenges and opportunities.Human mutation · 2014Review
- Illuminating p53 function in cancer with genetically engineered mouse models.Seminars in cell & developmental biology · 2014Review
- A range finding protocol to support design for transcriptomics experimentation: examples of in-vitro and in-vivo murine UV exposure.PloS one · 2014Article
- The relevance of the vitamin D endocrine system (VDES) for tumorigenesis, prevention, and treatment of non-melanoma skin cancer (NMSC): Present concepts and future perspectives.Dermato-endocrinology · 2013Review
- Mechanisms of p53 activation and physiological relevance in the developing kidney.American journal of physiology. Renal physiology · 2012Article
- The gain of function of p53 mutant p53S in promoting tumorigenesis by cross-talking with H-RasV12.International journal of biological sciences · 2012Article
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 2 countries.
Funding
Abstract
Phosphorylation is important for p53 protein stabilization and activation after DNA damage. Serine 389 of p53 is specifically phosphorylated after UV irradiation, whereas gamma radiation activates p53 through a different pathway. To study the in vivo significance of p53 phosphorylation at serine 389, we generated a physiological mouse model in which p53 phosphorylation at serine 389 is abolished by alanine substitution. Homozygous mutant p53.S389A mice are viable and have an apparently normal phenotype. However, cells isolated from these mice are partly compromised in transcriptional activation of p53 target genes and apoptosis after UV irradiation, whereas gamma radiation-induced responses are not affected. Moreover, p53.S389A mice show increased sensitivity to UV-induced skin tumor development, signifying the importance of serine 389 phosphorylation for the tumor-suppressive function of p53.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.