ReviewBMC cell biology2004
Control and maintenance of mammalian cell size.
Review in BMC cell biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Cell populations simulated in silico within SimulCell accurately reproduce the behaviour of experimental cell cultures.NPJ systems biology and applications · 2025Article
- Cell-to-cell signaling in cell populations with large cell size variability.Biophysical journal · 2025Article
- Cell size homeostasis is tightly controlled throughout the cell cycle.PLoS biology · 2024Article
- Polyploid cell dynamics and death before and after PEG-treatment of a NIH/3T3 derived culture: vinblastine effects on the regulation of cell subpopulations heterogeneity.Cell division · 2023Article
- What programs the size of animal cells?Frontiers in cell and developmental biology · 2022Review
- Human-Derived Corneal Epithelial Cells Expressing Cell Cycle Regulators as a New Resource forFrontiers in genetics · 2019Article
- Cell size control driven by the circadian clock and environment in cyanobacteria.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Modeling Cellular Noise Underlying Heterogeneous Cell Responses in the Epidermal Growth Factor Signaling Pathway.PLoS computational biology · 2016Article
- Evidence for P-Glycoprotein Involvement in Cell Volume Regulation Using Coulter Sizing in Flow Cytometry.International journal of molecular sciences · 2015Article
- Cell biology. On being the right (cell) size.Science (New York, N.Y.) · 2015Review
- Identification of new cell size control genes in S. cerevisiae.Cell division · 2012Article
- Direct observation of mammalian cell growth and size regulation.Nature methods · 2012Article
- The marginating-pulmonary immune compartment in rats: characteristics of continuous inflammation and activated NK cells.Journal of immunotherapy (Hagerstown, Md. : 1997) · 2010Article
- Cell growth and size homeostasis in proliferating animal cells.Science (New York, N.Y.) · 2009Article
- The death effector domain-containing DEDD supports S6K1 activity via preventing Cdk1-dependent inhibitory phosphorylation.The Journal of biological chemistry · 2009Article
- TRPM7 ion channels are required for sustained phosphoinositide 3-kinase signaling in lymphocytes.Cell metabolism · 2008Article
- Modes of cytometric bacterial DNA pattern: a tool for pursuing growth.Cell proliferation · 2007Review
- Membrane-elution analysis of content of cyclins A, B1, and E during the unperturbed mammalian cell cycle.Cell division · 2007Article
- Cytoplasmic volume condensation is an integral part of mitosis.Cell cycle (Georgetown, Tex.) · 2007Article
- Distinguishing between linear and exponential cell growth during the division cycle: single-cell studies, cell-culture studies, and the object of cell-cycle research.Theoretical biology & medical modelling · 2006Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundConlon and Raff propose that mammalian cells grow linearly during the division cycle. According to Conlon and Raff, cells growing linearly do not need a size checkpoint to maintain a constant distribution of cell sizes. If there is no cell-size-control system, then exponential growth is not allowed, as exponential growth, according to Conlon and Raff, would require a cell-size-control system. DISCUSSION: A reexamination of the model and experiments of Conlon and Raff indicates that exponential growth is fully compatible with cell size maintenance, and that mammalian cells have a system to regulate and maintain cell size that is related to the process of S-phase initiation. Mammalian cell size control and its relationship to growth rate-faster growing cells are larger than slower growing cells-is explained by the initiation of S phase occurring at a relatively constant cell size coupled with relatively invariant S- and G2-phase times as interdivision time varies. SUMMARY: This view of the mammalian cell cycle, the continuum model, explains the mass growth pattern during the division cycle, size maintenance, size determination, and the kinetics of cell-size change following a shift-up from slow to rapid growth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.