ArticleVirchows Archiv : an international journal of pathology2004
Factors of transforming growth factor beta signalling are co-regulated in human hepatocellular carcinoma.
Article in Virchows Archiv : an international journal of pathology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- Article
- Circulating levels of soluble urokinase plasminogen activator receptor predict outcome after resection of biliary tract cancer.JHEP reports : innovation in hepatology · 2020Article
- Nesprin-1 impact on tumorigenic cell phenotypes.Molecular biology reports · 2020Article
- The Influence of Adalimumab and Cyclosporine A on the Expression Profile of the Genes Related to TGFMediators of inflammation · 2020Article
- NGS-based transcriptome profiling reveals biomarkers for companion diagnostics of the TGF-β receptor blocker galunisertib in HCC.Cell death & disease · 2017Article
- Comparative analysis of TGF-β/Smad signaling dependent cytostasis in human hepatocellular carcinoma cell lines.PloS one · 2013Article
- TGF-β - an excellent servant but a bad master.Journal of translational medicine · 2012Review
- Hepatitis C virus-host interactions: Etiopathogenesis and therapeutic strategies.World journal of experimental medicine · 2012Article
- Novel therapeutic strategies for targeting liver cancer stem cells.International journal of biological sciences · 2011Review
- Impairment of transforming growth factor beta signaling in caveolin-1-deficient hepatocytes: role in liver regeneration.The Journal of biological chemistry · 2010Article
- SKI knockdown inhibits human melanoma tumor growth in vivo.Pigment cell & melanoma research · 2009Article
- Article
- Liver stem cells and molecular signaling pathways in hepatocellular carcinoma.Gastrointestinal cancer research : GCR · 2007Article
- Review
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transforming growth factor beta (TGFbeta) is a central mitoinhibitory factor for epithelial cells, and alterations of TGFbeta signalling have been demonstrated in many different human cancers. We have analysed human hepatocellular carcinomas (HCCs) for potential pro-tumourigenic alterations in regard to expression of Smad4 and mutations and expression changes of the pro-oncogenic transcriptional co-repressors Ski and SnoN, as well as mRNA levels of matrix metalloproteinase-2 (MMP2), which is transcriptionally regulated by TGFbeta. Smad4 mRNA was detected in all HCCs; while, using immunohistology, loss of Smad4 expression was found in 10% of HCCs. Neither mutations in the transformation-relevant sequences nor significant pro-tumourigenic expression changes of the Ski and SnoN genes were detected. In HCC cell lines, expression of both genes was regulated, potentially involving phosphorylation. Ski showed a distinct nuclear speckled pattern, indicating recruitment to active transcription complexes. MMP2 mRNA levels were increased in 19% of HCCs, whereas MMP2 mRNA was not detectable in HCC cell lines, suggesting that MMP2 was derived only from tumour stroma cells. Transcript levels of Smad4, Ski, SnoN and MMP2 correlated well. These data argue against a significant role of Ski and SnoN in human hepatocarcinogenesis and suggest that, in the majority of HCCs, the analysed factors are co-regulated by an upstream mechanism, potentially by TGFbeta itself.
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